Regulation of Tissue Fibrosis by the Biomechanical Environment
Joint Authors
Carver, Wayne
Goldsmith, Edie C.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The biomechanical environment plays a fundamental role in embryonic development, tissue maintenance, and pathogenesis.
Mechanical forces play particularly important roles in the regulation of connective tissues including not only bone and cartilage but also the interstitial tissues of most organs.
In vivo studies have correlated changes in mechanical load to modulation of the extracellular matrix and have indicated that increased mechanical force contributes to the enhanced expression and deposition of extracellular matrix components or fibrosis.
Pathological fibrosis contributes to dysfunction of many organ systems.
A variety of in vitro models have been utilized to evaluate the effects of mechanical force on extracellular matrix-producing cells.
In general, application of mechanical stretch, fluid flow, and compression results in increased expression of extracellular matrix components.
More recent studies have indicated that tissue rigidity also provides profibrotic signals to cells.
The mechanisms whereby cells detect mechanical signals and transduce them into biochemical responses have received considerable attention.
Cell surface receptors for extracellular matrix components and intracellular signaling pathways are instrumental in the mechanotransduction process.
Understanding how mechanical signals are transmitted from the microenvironment will identify novel therapeutic targets for fibrosis and other pathological conditions.
American Psychological Association (APA)
Carver, Wayne& Goldsmith, Edie C.. 2013. Regulation of Tissue Fibrosis by the Biomechanical Environment. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1003248
Modern Language Association (MLA)
Carver, Wayne& Goldsmith, Edie C.. Regulation of Tissue Fibrosis by the Biomechanical Environment. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1003248
American Medical Association (AMA)
Carver, Wayne& Goldsmith, Edie C.. Regulation of Tissue Fibrosis by the Biomechanical Environment. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1003248
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003248