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Assessment of Cytotoxicity, Fetotoxicity, and Teratogenicity of Plathymenia reticulata Benth Barks Aqueous Extract
المؤلفون المشاركون
de Barros Leite Albuquerque, Lia
Dal Belo, Cháriston André
dos Santos, Marcio Galdino
Lopes, Patricia Santos
Gerenutti, Marli
Oshima-Franco, Yoko
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-22
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Scientific assessment of harmful interactions of chemicals over the entire reproductive cycle are divided into three segments based on the period: from premating and mating to implantation (I), from implantation to major organogenesis (II), and late pregnancy and postnatal development (III).
We combined the segments I and II to assess Plathymenia reticulata aqueous extract safety.
In order to investigate reproductive toxicity (segment I), pregnant rats received orally 0.5 or 1.0 g/kg of extract, daily, during 18 days.
These concentrations were determined by a preliminary in vitro LD50 test in CHO-k1 cells.
A control group received deionized water.
The offspring was removed at the 19th day, by caesarean, and a teratology study (segment II) was carried out.
The corpora lutea, implants, resorptions, live, and dead fetuses were then counted.
Placenta and fetuses were weighted.
External and visceral morphology were provided by the fixation of fetuses in Bouin, whereas skeletal analysis was carried out on the diaphanizated ones.
The increase in the weights of placenta and fetuses was the only abnormality observed.
Since there was no sign of alteration on reproduction parameters at our experimental conditions, we conclude that P.
reticulata aqueous extract is safe at 0.5 to 1.0 g/kg and is not considered teratogenic.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
de Barros Leite Albuquerque, Lia& Dal Belo, Cháriston André& dos Santos, Marcio Galdino& Lopes, Patricia Santos& Gerenutti, Marli& Oshima-Franco, Yoko. 2013. Assessment of Cytotoxicity, Fetotoxicity, and Teratogenicity of Plathymenia reticulata Benth Barks Aqueous Extract. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1003308
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
de Barros Leite Albuquerque, Lia…[et al.]. Assessment of Cytotoxicity, Fetotoxicity, and Teratogenicity of Plathymenia reticulata Benth Barks Aqueous Extract. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1003308
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
de Barros Leite Albuquerque, Lia& Dal Belo, Cháriston André& dos Santos, Marcio Galdino& Lopes, Patricia Santos& Gerenutti, Marli& Oshima-Franco, Yoko. Assessment of Cytotoxicity, Fetotoxicity, and Teratogenicity of Plathymenia reticulata Benth Barks Aqueous Extract. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1003308
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1003308
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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