Assessment of Cytotoxicity, Fetotoxicity, and Teratogenicity of Plathymenia reticulata Benth Barks Aqueous Extract
Joint Authors
de Barros Leite Albuquerque, Lia
Dal Belo, Cháriston André
dos Santos, Marcio Galdino
Lopes, Patricia Santos
Gerenutti, Marli
Oshima-Franco, Yoko
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Scientific assessment of harmful interactions of chemicals over the entire reproductive cycle are divided into three segments based on the period: from premating and mating to implantation (I), from implantation to major organogenesis (II), and late pregnancy and postnatal development (III).
We combined the segments I and II to assess Plathymenia reticulata aqueous extract safety.
In order to investigate reproductive toxicity (segment I), pregnant rats received orally 0.5 or 1.0 g/kg of extract, daily, during 18 days.
These concentrations were determined by a preliminary in vitro LD50 test in CHO-k1 cells.
A control group received deionized water.
The offspring was removed at the 19th day, by caesarean, and a teratology study (segment II) was carried out.
The corpora lutea, implants, resorptions, live, and dead fetuses were then counted.
Placenta and fetuses were weighted.
External and visceral morphology were provided by the fixation of fetuses in Bouin, whereas skeletal analysis was carried out on the diaphanizated ones.
The increase in the weights of placenta and fetuses was the only abnormality observed.
Since there was no sign of alteration on reproduction parameters at our experimental conditions, we conclude that P.
reticulata aqueous extract is safe at 0.5 to 1.0 g/kg and is not considered teratogenic.
American Psychological Association (APA)
de Barros Leite Albuquerque, Lia& Dal Belo, Cháriston André& dos Santos, Marcio Galdino& Lopes, Patricia Santos& Gerenutti, Marli& Oshima-Franco, Yoko. 2013. Assessment of Cytotoxicity, Fetotoxicity, and Teratogenicity of Plathymenia reticulata Benth Barks Aqueous Extract. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1003308
Modern Language Association (MLA)
de Barros Leite Albuquerque, Lia…[et al.]. Assessment of Cytotoxicity, Fetotoxicity, and Teratogenicity of Plathymenia reticulata Benth Barks Aqueous Extract. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1003308
American Medical Association (AMA)
de Barros Leite Albuquerque, Lia& Dal Belo, Cháriston André& dos Santos, Marcio Galdino& Lopes, Patricia Santos& Gerenutti, Marli& Oshima-Franco, Yoko. Assessment of Cytotoxicity, Fetotoxicity, and Teratogenicity of Plathymenia reticulata Benth Barks Aqueous Extract. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1003308
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003308