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Gamma Knife Surgery as Monotherapy with Clinically Relevant Doses Prolongs Survival in a Human GBM Xenograft Model
المؤلفون المشاركون
Sandvei Skeie, Bente
Wang, Jian
Dodoo, Ernest
Heggdal, Jan Ingeman
Grønli, Janne
Sleire, Linda
Bragstad, Sidsel
Ganz, Jeremy C.
Chekenya, Martha
Mørk, Sverre
Pedersen, Paal-Henning
Enger, Per Øyvind
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-10
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Object.
Gamma knife surgery (GKS) may be used for recurring glioblastomas (GBMs).
However, patients have then usually undergone multimodal treatment, which makes it difficult to specifically validate GKS independent of established treatments.
Thus, we developed an experimental brain tumor model to assess the efficacy and radiotoxicity associated with GKS.
Methods.
GBM xenografts were implanted intracerebrally in nude rats, and engraftment was confirmed with MRI.
The rats were allocated to GKS, with margin doses of 12 Gy or 18 Gy, or to no treatment.
Survival time was recorded, tumor sections were examined, and radiotoxicity was evaluated in a behavioral open field test.
Results.
In the first series, survival from the time of implantation was 96 days in treated rats and 72 days in controls (P<0.001).
In a second experiment, survival was 72 days in the treatment group versus 54 days in controls (P<0.006).
Polynuclear macrophages and fibrosis was seen in groups subjected to GKS.
Untreated rats with GBM xenografts displayed less mobility than GKS-treated animals in the open field test 4 weeks after treatment (P=0.04).
Conclusion.
GKS administered with clinically relevant doses prolongs survival in rats harboring GBM xenografts, and the associated toxicity is mild.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sandvei Skeie, Bente& Wang, Jian& Dodoo, Ernest& Heggdal, Jan Ingeman& Grønli, Janne& Sleire, Linda…[et al.]. 2013. Gamma Knife Surgery as Monotherapy with Clinically Relevant Doses Prolongs Survival in a Human GBM Xenograft Model. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1003360
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sandvei Skeie, Bente…[et al.]. Gamma Knife Surgery as Monotherapy with Clinically Relevant Doses Prolongs Survival in a Human GBM Xenograft Model. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1003360
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sandvei Skeie, Bente& Wang, Jian& Dodoo, Ernest& Heggdal, Jan Ingeman& Grønli, Janne& Sleire, Linda…[et al.]. Gamma Knife Surgery as Monotherapy with Clinically Relevant Doses Prolongs Survival in a Human GBM Xenograft Model. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1003360
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1003360
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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