Expression of Bmi-1 in Pediatric Brain Tumors as a New Independent Prognostic Marker of Patient Survival
المؤلفون المشاركون
Farivar, Shirin
Zati Keikha, Reza
Shiari, Reza
Jadali, Farzaneh
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-28
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
|Objectives.
The B-cell-specific moloney leukemia virus insertion site 1 (the Bmi-1) gene is an important member in the family of polycomb group (PcG) genes that plays an oncogenic role in several types of cancer, but it’s expression as a prognostic marker in pediatric brain tumors has not been indicated.
Materials and Methods.
The Bmi-1 gene expression, clinic pathological and prognostic significance in a series of pediatric brain tumors were examined by real-time PCR method in 56 pediatric brain tumors.
Results.
The Bmi-1 gene expression in various types of pediatric brain tumors compared to that in normal brain tissue was 4.85-fold.
The relative expression varied from 8.64-fold in ependymomas to 2.89-fold in other types.
Expression level in high-grade tumors compared to that in low-grade tumors was 2.5 times.
In univariate survival analysis of the pediatric brain tumors, a significant association of high expression of the Bmi-1 with patient survival was demonstrated.
In multivariate analysis, the Bmi-1 high expression provided significant independent prognostic factors.
Conclusion.
Increased expression of the Bmi-1 in pediatric brain tumors may be important in the acquisition of an aggressive phenotype.
In addition, it can be used as a strong and independent molecular marker of prognosis in pediatric brain tumors.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Farivar, Shirin& Zati Keikha, Reza& Shiari, Reza& Jadali, Farzaneh. 2013. Expression of Bmi-1 in Pediatric Brain Tumors as a New Independent Prognostic Marker of Patient Survival. BioMed Research International،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1003665
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Farivar, Shirin…[et al.]. Expression of Bmi-1 in Pediatric Brain Tumors as a New Independent Prognostic Marker of Patient Survival. BioMed Research International No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1003665
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Farivar, Shirin& Zati Keikha, Reza& Shiari, Reza& Jadali, Farzaneh. Expression of Bmi-1 in Pediatric Brain Tumors as a New Independent Prognostic Marker of Patient Survival. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1003665
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1003665
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر