Expression of Bmi-1 in Pediatric Brain Tumors as a New Independent Prognostic Marker of Patient Survival
Joint Authors
Farivar, Shirin
Zati Keikha, Reza
Shiari, Reza
Jadali, Farzaneh
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-28
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
|Objectives.
The B-cell-specific moloney leukemia virus insertion site 1 (the Bmi-1) gene is an important member in the family of polycomb group (PcG) genes that plays an oncogenic role in several types of cancer, but it’s expression as a prognostic marker in pediatric brain tumors has not been indicated.
Materials and Methods.
The Bmi-1 gene expression, clinic pathological and prognostic significance in a series of pediatric brain tumors were examined by real-time PCR method in 56 pediatric brain tumors.
Results.
The Bmi-1 gene expression in various types of pediatric brain tumors compared to that in normal brain tissue was 4.85-fold.
The relative expression varied from 8.64-fold in ependymomas to 2.89-fold in other types.
Expression level in high-grade tumors compared to that in low-grade tumors was 2.5 times.
In univariate survival analysis of the pediatric brain tumors, a significant association of high expression of the Bmi-1 with patient survival was demonstrated.
In multivariate analysis, the Bmi-1 high expression provided significant independent prognostic factors.
Conclusion.
Increased expression of the Bmi-1 in pediatric brain tumors may be important in the acquisition of an aggressive phenotype.
In addition, it can be used as a strong and independent molecular marker of prognosis in pediatric brain tumors.
American Psychological Association (APA)
Farivar, Shirin& Zati Keikha, Reza& Shiari, Reza& Jadali, Farzaneh. 2013. Expression of Bmi-1 in Pediatric Brain Tumors as a New Independent Prognostic Marker of Patient Survival. BioMed Research International،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1003665
Modern Language Association (MLA)
Farivar, Shirin…[et al.]. Expression of Bmi-1 in Pediatric Brain Tumors as a New Independent Prognostic Marker of Patient Survival. BioMed Research International No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1003665
American Medical Association (AMA)
Farivar, Shirin& Zati Keikha, Reza& Shiari, Reza& Jadali, Farzaneh. Expression of Bmi-1 in Pediatric Brain Tumors as a New Independent Prognostic Marker of Patient Survival. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1003665
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003665