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The Cardioprotective Effect of Hypertonic Saline Is Associated with Inhibitory Effect on Macrophage Migration Inhibitory Factor in Sepsis
المؤلفون المشاركون
Wang, Yi-Li
Lam, Kwok-Keung
Cheng, Pao-Yun
Kung, Ching-Wen
Chen, Shu-Ying
Chao, Chun-Chih
Hwang, Hwong-Ru
Chung, Ming-Ting
Lee, Yen-Mei
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-26
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Sepsis can cause myocardial dysfunction, which contributes to the high mortality of sepsis.
Hypertonic saline (HS) has been reported to increase myocardial contractility in sepsis.
In the present study, mechanisms of action of HS resuscitation (4 mL of 7.5% NaCl per kilogram) on cardiac function have been evaluated in septic rats.
HS was administered 1 h after LPS (10 mg/kg, i.v.) challenge.
The mean arterial blood pressure significantly decreased 4 h after LPS challenge, and septic shock was observed at the end of experiment (6 h).
Posttreatment with HS prevented hypotension caused by LPS and significantly improved cardiac function, evidenced by increases in left ventricular developed pressure, mean +dP/dt and -dP/dt.
The amplitude of electrical-stimulated intracellular Ca2+ transient in isolated single cardiomyocytes was significantly reduced after 6 h LPS insult, which was recovered by HS.
In addition, LPS resulted in significant increases in neutrophil myeloperoxidase activity, macrophage migration inhibitory factor (MIF), and NF-κB phospho-p65 protein levels in myocardium at 6 h, which were significantly attenuated by HS.
In conclusion, HS improved myocardial contractility and prevented circulatory failure induced by endotoxemia, which may attribute to improvement of intracellular calcium handling process and inhibitory effects on neutrophil infiltration and MIF production in hearts.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Yi-Li& Lam, Kwok-Keung& Cheng, Pao-Yun& Kung, Ching-Wen& Chen, Shu-Ying& Chao, Chun-Chih…[et al.]. 2013. The Cardioprotective Effect of Hypertonic Saline Is Associated with Inhibitory Effect on Macrophage Migration Inhibitory Factor in Sepsis. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1003688
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Yi-Li…[et al.]. The Cardioprotective Effect of Hypertonic Saline Is Associated with Inhibitory Effect on Macrophage Migration Inhibitory Factor in Sepsis. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1003688
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Yi-Li& Lam, Kwok-Keung& Cheng, Pao-Yun& Kung, Ching-Wen& Chen, Shu-Ying& Chao, Chun-Chih…[et al.]. The Cardioprotective Effect of Hypertonic Saline Is Associated with Inhibitory Effect on Macrophage Migration Inhibitory Factor in Sepsis. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1003688
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1003688
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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