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The Cardioprotective Effect of Hypertonic Saline Is Associated with Inhibitory Effect on Macrophage Migration Inhibitory Factor in Sepsis
Joint Authors
Wang, Yi-Li
Lam, Kwok-Keung
Cheng, Pao-Yun
Kung, Ching-Wen
Chen, Shu-Ying
Chao, Chun-Chih
Hwang, Hwong-Ru
Chung, Ming-Ting
Lee, Yen-Mei
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Sepsis can cause myocardial dysfunction, which contributes to the high mortality of sepsis.
Hypertonic saline (HS) has been reported to increase myocardial contractility in sepsis.
In the present study, mechanisms of action of HS resuscitation (4 mL of 7.5% NaCl per kilogram) on cardiac function have been evaluated in septic rats.
HS was administered 1 h after LPS (10 mg/kg, i.v.) challenge.
The mean arterial blood pressure significantly decreased 4 h after LPS challenge, and septic shock was observed at the end of experiment (6 h).
Posttreatment with HS prevented hypotension caused by LPS and significantly improved cardiac function, evidenced by increases in left ventricular developed pressure, mean +dP/dt and -dP/dt.
The amplitude of electrical-stimulated intracellular Ca2+ transient in isolated single cardiomyocytes was significantly reduced after 6 h LPS insult, which was recovered by HS.
In addition, LPS resulted in significant increases in neutrophil myeloperoxidase activity, macrophage migration inhibitory factor (MIF), and NF-κB phospho-p65 protein levels in myocardium at 6 h, which were significantly attenuated by HS.
In conclusion, HS improved myocardial contractility and prevented circulatory failure induced by endotoxemia, which may attribute to improvement of intracellular calcium handling process and inhibitory effects on neutrophil infiltration and MIF production in hearts.
American Psychological Association (APA)
Wang, Yi-Li& Lam, Kwok-Keung& Cheng, Pao-Yun& Kung, Ching-Wen& Chen, Shu-Ying& Chao, Chun-Chih…[et al.]. 2013. The Cardioprotective Effect of Hypertonic Saline Is Associated with Inhibitory Effect on Macrophage Migration Inhibitory Factor in Sepsis. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1003688
Modern Language Association (MLA)
Wang, Yi-Li…[et al.]. The Cardioprotective Effect of Hypertonic Saline Is Associated with Inhibitory Effect on Macrophage Migration Inhibitory Factor in Sepsis. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1003688
American Medical Association (AMA)
Wang, Yi-Li& Lam, Kwok-Keung& Cheng, Pao-Yun& Kung, Ching-Wen& Chen, Shu-Ying& Chao, Chun-Chih…[et al.]. The Cardioprotective Effect of Hypertonic Saline Is Associated with Inhibitory Effect on Macrophage Migration Inhibitory Factor in Sepsis. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1003688
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003688