Identification of Interconnected Markers for T-Cell Acute Lymphoblastic Leukemia
المؤلفون المشاركون
Guven Maiorov, Emine
Keskin, Ozlem
Hatirnaz Ng, Ozden
Ozbek, Ugur
Gursoy, Attila
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-20، 20ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-15
دولة النشر
مصر
عدد الصفحات
20
التخصصات الرئيسية
الملخص EN
T-cell acute lymphoblastic leukemia (T-ALL) is a complex disease, resulting from proliferation of differentially arrested immature T cells.
The molecular mechanisms and the genes involved in the generation of T-ALL remain largely undefined.
In this study, we propose a set of genes to differentiate individuals with T-ALL from the nonleukemia/healthy ones and genes that are not differential themselves but interconnected with highly differentially expressed ones.
We provide new suggestions for pathways involved in the cause of T-ALL and show that network-based classification techniques produce fewer genes with more meaningful and successful results than expression-based approaches.
We have identified 19 significant subnetworks, containing 102 genes.
The classification/prediction accuracies of subnetworks are considerably high, as high as 98%.
Subnetworks contain 6 nondifferentially expressed genes, which could potentially participate in pathogenesis of T-ALL.
Although these genes are not differential, they may serve as biomarkers if their loss/gain of function contributes to generation of T-ALL via SNPs.
We conclude that transcription factors, zinc-ion-binding proteins, and tyrosine kinases are the important protein families to trigger T-ALL.
These potential disease-causing genes in our subnetworks may serve as biomarkers, alternative to the traditional ones used for the diagnosis of T-ALL, and help understand the pathogenesis of the disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Guven Maiorov, Emine& Keskin, Ozlem& Hatirnaz Ng, Ozden& Ozbek, Ugur& Gursoy, Attila. 2013. Identification of Interconnected Markers for T-Cell Acute Lymphoblastic Leukemia. BioMed Research International،Vol. 2013, no. 2013, pp.1-20.
https://search.emarefa.net/detail/BIM-1003715
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Guven Maiorov, Emine…[et al.]. Identification of Interconnected Markers for T-Cell Acute Lymphoblastic Leukemia. BioMed Research International No. 2013 (2013), pp.1-20.
https://search.emarefa.net/detail/BIM-1003715
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Guven Maiorov, Emine& Keskin, Ozlem& Hatirnaz Ng, Ozden& Ozbek, Ugur& Gursoy, Attila. Identification of Interconnected Markers for T-Cell Acute Lymphoblastic Leukemia. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-20.
https://search.emarefa.net/detail/BIM-1003715
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1003715
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر