Identification of Interconnected Markers for T-Cell Acute Lymphoblastic Leukemia
Joint Authors
Guven Maiorov, Emine
Keskin, Ozlem
Hatirnaz Ng, Ozden
Ozbek, Ugur
Gursoy, Attila
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-15
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
T-cell acute lymphoblastic leukemia (T-ALL) is a complex disease, resulting from proliferation of differentially arrested immature T cells.
The molecular mechanisms and the genes involved in the generation of T-ALL remain largely undefined.
In this study, we propose a set of genes to differentiate individuals with T-ALL from the nonleukemia/healthy ones and genes that are not differential themselves but interconnected with highly differentially expressed ones.
We provide new suggestions for pathways involved in the cause of T-ALL and show that network-based classification techniques produce fewer genes with more meaningful and successful results than expression-based approaches.
We have identified 19 significant subnetworks, containing 102 genes.
The classification/prediction accuracies of subnetworks are considerably high, as high as 98%.
Subnetworks contain 6 nondifferentially expressed genes, which could potentially participate in pathogenesis of T-ALL.
Although these genes are not differential, they may serve as biomarkers if their loss/gain of function contributes to generation of T-ALL via SNPs.
We conclude that transcription factors, zinc-ion-binding proteins, and tyrosine kinases are the important protein families to trigger T-ALL.
These potential disease-causing genes in our subnetworks may serve as biomarkers, alternative to the traditional ones used for the diagnosis of T-ALL, and help understand the pathogenesis of the disease.
American Psychological Association (APA)
Guven Maiorov, Emine& Keskin, Ozlem& Hatirnaz Ng, Ozden& Ozbek, Ugur& Gursoy, Attila. 2013. Identification of Interconnected Markers for T-Cell Acute Lymphoblastic Leukemia. BioMed Research International،Vol. 2013, no. 2013, pp.1-20.
https://search.emarefa.net/detail/BIM-1003715
Modern Language Association (MLA)
Guven Maiorov, Emine…[et al.]. Identification of Interconnected Markers for T-Cell Acute Lymphoblastic Leukemia. BioMed Research International No. 2013 (2013), pp.1-20.
https://search.emarefa.net/detail/BIM-1003715
American Medical Association (AMA)
Guven Maiorov, Emine& Keskin, Ozlem& Hatirnaz Ng, Ozden& Ozbek, Ugur& Gursoy, Attila. Identification of Interconnected Markers for T-Cell Acute Lymphoblastic Leukemia. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-20.
https://search.emarefa.net/detail/BIM-1003715
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003715