The Role of Bone Marrow Mesenchymal Stem Cells in the Treatment of Acute Liver Failure
المؤلفون المشاركون
Yuan, Shufang
Jiang, Tao
Sun, Lihua
Zheng, Rongjiong
Ahat, Nizam
Zhang, Yuexin
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-10
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
This study is to investigate the effects of bone marrow mesenchymal stem cell (BMSC) transplantation on acute liver failure (ALF).
Methods.
BMSCs were separated from rat bone marrow, cultured, and identified by flow cytometry.
Rat model with ALF was established by injecting D-galactosamine and lipopolysaccharide.
Rats were randomly divided into the control group and BMSC transplantation group.
The serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured at 24 h, 120 h, and 168 h after BMSC transplantation.
Apoptosis was detected by TUNEL assay.
The expression of VEGF and AFP proteins was detected by immunofluorescence.
Caspase-1 and IL-18 proteins and mRNA were detected by immunohistochemistry and RT-PCR.
Results.
Compared with the control group, levels of ALT, AST, caspase-1 and IL-18 proteins, and mRNA in the transplantation group were significantly lower at 120 h and 168 h after BMSCs transplantation.
Apoptosis was inhibited by BMSCs transplantation.
The VEGF protein levels were increased with the improvement of liver function, and the AFP protein levels were increased with the deterioration of the liver function after BMSCs transplantation.
Conclusions.
BMSCs transplantation can improve liver function and inhibit hepatocyte apoptosis as well as promote hepatocyte proliferation in rat model with ALF.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yuan, Shufang& Jiang, Tao& Sun, Lihua& Zheng, Rongjiong& Ahat, Nizam& Zhang, Yuexin. 2013. The Role of Bone Marrow Mesenchymal Stem Cells in the Treatment of Acute Liver Failure. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1003800
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yuan, Shufang…[et al.]. The Role of Bone Marrow Mesenchymal Stem Cells in the Treatment of Acute Liver Failure. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1003800
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yuan, Shufang& Jiang, Tao& Sun, Lihua& Zheng, Rongjiong& Ahat, Nizam& Zhang, Yuexin. The Role of Bone Marrow Mesenchymal Stem Cells in the Treatment of Acute Liver Failure. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1003800
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1003800
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر