The Predictive Value of Interim and Final [18F] Fluorodeoxyglucose Positron Emission Tomography after Rituximab-Chemotherapy in the Treatment of Non-Hodgkin's Lymphoma: A Meta-Analysis

الملخص EN

Background and Purpose.

The aim of this study is to determine the prognostic value of interim and final FDG-PET in major histotypes of B-cell NHL patients treated with rituximab containing-chemotherapy.

Methods.

We searched for articles published in English, limited to lymphoma, rituximab, and FDG-PET, and dedicated to deal with the impact on progression and survival.

The log hazard ratios (HR) and their variances were estimated.

Results.

A PubMed and Scopus review of published trials identified 13 studies of Progression-free survival (PFS) and overall survival (OS) which were set as the main outcome measures.

The combined HRs of I-PET for PFS and OS in DLBCL were 4.4 (P=0.11) and 3.99 (P=0.46), respectively.

The combined HRs of F-PET for PFS and OS in DLBCL were 5.91 (P=0.39) and 6.75 (P=0.92), respectively.

Regarding to non-DLBCL with F-PET, the combined HRs of F-PET for PFS and OS were 4.05 (P=0.79) and 5.1 (P=0.51), respectively.

No publication bias existed.

Conclusion.

In DLBCL, both I-PET and F-PET can be performed for survival and progression analysis.

But in other B-cell subtypes such as follicular lymphoma (FL) and mantle cell lymphoma (MCL), it would be necessary to perform F-PET for predictive purposes.