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Expression and Complex Formation of MMP9, MMP2, NGAL, and TIMP1 in Porcine Myocardium but Not in Skeletal Muscles in Male Pigs with Tachycardia-Induced Systolic Heart Failure
المؤلفون المشاركون
Kiczak, Liliana
Tomaszek, Alicja
Bania, Jacek
Paslawska, Urszula
Zacharski, Maciej
Noszczyk-Nowak, Agnieszka
Janiszewski, Adrian
Skrzypczak, Piotr
Ardehali, Hossein
Jankowska, Ewa A.
Ponikowski, Piotr
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-04-22
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Matrix metalloproteinases (MMPs) are involved in the remodeling of extracellular matrix in various tissues.
Their functioning could be related to the formation of complexes, containing MMP9, MMP2, tissue inhibitor of metalloproteinases type 1 (TIMP1), and neutrophil gelatinase-associated lipocalin (NGAL).
Such complexes have not been investigated in either myocardial or skeletal muscles.
We examined 20 male pigs with heart failure (HF), and 5 sham-operated animals.
There were no differences in the mRNA expression of MMP9, MMP2, TIMP1, and NGAL between diseased and healthy animals, in either left ventricle (LV) myocardium or skeletal muscles.
In LV from both diseased and healthy animals, in nonreducing and nondenaturing conditions, we demonstrated the presence of high molecular weight (HMW) complexes (130, 170, and 220 kDa) containing MMP9, TIMP1, and NGAL (also MMP2 in 220 kDa complex) without proteolytic activity, and a proteolytically active 115 kDa MMP9 form together with 72 and 68 kDa bands (proMMP2 and MMP2).
Proteolytically active bands were also spontaneously released from HMW complexes.
In skeletal muscles from both diseased and healthy animals, in nonreducing and nondenaturing conditions, we found no HMW complexes, and proteolytic activity was associated with the presence of 72 and 68 kDa bands (proMMP2 and MMP2).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kiczak, Liliana& Tomaszek, Alicja& Bania, Jacek& Paslawska, Urszula& Zacharski, Maciej& Noszczyk-Nowak, Agnieszka…[et al.]. 2013. Expression and Complex Formation of MMP9, MMP2, NGAL, and TIMP1 in Porcine Myocardium but Not in Skeletal Muscles in Male Pigs with Tachycardia-Induced Systolic Heart Failure. BioMed Research International،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1003889
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kiczak, Liliana…[et al.]. Expression and Complex Formation of MMP9, MMP2, NGAL, and TIMP1 in Porcine Myocardium but Not in Skeletal Muscles in Male Pigs with Tachycardia-Induced Systolic Heart Failure. BioMed Research International No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1003889
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kiczak, Liliana& Tomaszek, Alicja& Bania, Jacek& Paslawska, Urszula& Zacharski, Maciej& Noszczyk-Nowak, Agnieszka…[et al.]. Expression and Complex Formation of MMP9, MMP2, NGAL, and TIMP1 in Porcine Myocardium but Not in Skeletal Muscles in Male Pigs with Tachycardia-Induced Systolic Heart Failure. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1003889
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1003889
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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