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Leptin Increases Blood Pressure and Markers of Endothelial Activation during Pregnancy in Rats
المؤلفون المشاركون
Ibrahim, Hisham Saleh
Omar, Effat
Froemming, Gabrielle Ruth Anisah
Singh, Harbindar Jeet
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-19
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Raised leptin levels have been reported in the placentae and serum of women with elevated blood pressure and proteinuria during pregnancy.
The role of leptin in this however remains unknown.
This study investigates the effect of leptin administration on systolic blood pressure (SBP) and proteinuria and serum markers of endothelial activation during pregnancy in Sprague Dawley rats.
From day 1 of pregnancy, 24 rats were randomised into those given either saline (group 1) or leptin at 60 or 120 μg/kg/body weight/day (groups 2 and 3 resp.).
SBP was measured every 5 days and 24-h urinary protein was measured at days 0 and 20 of pregnancy.
Animals were euthanised on day 20 of pregnancy, and serum was collected for estimation of E-selectin and ICAM-1.
Compared to group 1, SBP during the latter part of the pregnancy was significantly higher in the leptin-treated group (P<0.01).
Urinary protein excretion, serum E-selectin, and ICAM-1 were significantly higher in leptin-treated rats (P<0.05).
It seems that leptin administration to normotensive Sprague Dawley rats during pregnancy significantly increases SBP, urinary protein excretion, and markers of endothelial activation.
However, further studies are required to examine the underlying mechanism responsible for this and its relevance to preeclampsia in humans.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ibrahim, Hisham Saleh& Omar, Effat& Froemming, Gabrielle Ruth Anisah& Singh, Harbindar Jeet. 2013. Leptin Increases Blood Pressure and Markers of Endothelial Activation during Pregnancy in Rats. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1003943
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ibrahim, Hisham Saleh…[et al.]. Leptin Increases Blood Pressure and Markers of Endothelial Activation during Pregnancy in Rats. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1003943
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ibrahim, Hisham Saleh& Omar, Effat& Froemming, Gabrielle Ruth Anisah& Singh, Harbindar Jeet. Leptin Increases Blood Pressure and Markers of Endothelial Activation during Pregnancy in Rats. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1003943
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1003943
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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