Leptin Increases Blood Pressure and Markers of Endothelial Activation during Pregnancy in Rats
Joint Authors
Ibrahim, Hisham Saleh
Omar, Effat
Froemming, Gabrielle Ruth Anisah
Singh, Harbindar Jeet
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-19
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Raised leptin levels have been reported in the placentae and serum of women with elevated blood pressure and proteinuria during pregnancy.
The role of leptin in this however remains unknown.
This study investigates the effect of leptin administration on systolic blood pressure (SBP) and proteinuria and serum markers of endothelial activation during pregnancy in Sprague Dawley rats.
From day 1 of pregnancy, 24 rats were randomised into those given either saline (group 1) or leptin at 60 or 120 μg/kg/body weight/day (groups 2 and 3 resp.).
SBP was measured every 5 days and 24-h urinary protein was measured at days 0 and 20 of pregnancy.
Animals were euthanised on day 20 of pregnancy, and serum was collected for estimation of E-selectin and ICAM-1.
Compared to group 1, SBP during the latter part of the pregnancy was significantly higher in the leptin-treated group (P<0.01).
Urinary protein excretion, serum E-selectin, and ICAM-1 were significantly higher in leptin-treated rats (P<0.05).
It seems that leptin administration to normotensive Sprague Dawley rats during pregnancy significantly increases SBP, urinary protein excretion, and markers of endothelial activation.
However, further studies are required to examine the underlying mechanism responsible for this and its relevance to preeclampsia in humans.
American Psychological Association (APA)
Ibrahim, Hisham Saleh& Omar, Effat& Froemming, Gabrielle Ruth Anisah& Singh, Harbindar Jeet. 2013. Leptin Increases Blood Pressure and Markers of Endothelial Activation during Pregnancy in Rats. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1003943
Modern Language Association (MLA)
Ibrahim, Hisham Saleh…[et al.]. Leptin Increases Blood Pressure and Markers of Endothelial Activation during Pregnancy in Rats. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1003943
American Medical Association (AMA)
Ibrahim, Hisham Saleh& Omar, Effat& Froemming, Gabrielle Ruth Anisah& Singh, Harbindar Jeet. Leptin Increases Blood Pressure and Markers of Endothelial Activation during Pregnancy in Rats. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1003943
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003943