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Citrus Flavanones Affect Hepatic Fatty Acid Oxidation in Rats by Acting as Prooxidant Agents
المؤلفون المشاركون
Constantin, Rodrigo Polimeni
Nascimento, Gilson Soares do
Constantin, Renato Polimeni
Salgueiro, Clairce Luzia
Bracht, Adelar
Ishii-Iwamoto, Emy Luiza
Yamamoto, Nair Seiko
Constantin, Jorgete
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-31
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Citrus flavonoids have a wide range of biological activities and positive health effects on mammalian cells because of their antioxidant properties.
However, they also act as prooxidants and thus may interfere with metabolic pathways.
The purpose of this work was to evaluate the effects of three citrus flavanones, hesperidin, hesperetin, and naringenin, on several parameters linked to fatty acid oxidation in mitochondria, peroxisomes, and perfused livers of rats.
When exogenous octanoate was used as substrate, hesperetin and naringenin reduced the mitochondrial NADH/NAD+ ratio and stimulated the citric acid cycle without significant changes on oxygen uptake or ketogenesis.
When fatty acid oxidation from endogenous sources was evaluated, hesperetin and naringenin strongly reduced the mitochondrial NADH/NAD+ ratio.
They also inhibited both oxygen uptake and ketogenesis and stimulated the citric acid cycle.
Hesperidin, on the other hand, had little to no effect on these parameters.
These results confirm the hypothesis that citrus flavanones are able to induce a more oxidised state in liver cells, altering parameters related to hepatic fatty acid oxidation.
The prooxidant effect is most likely a consequence of the ability of these substances to oxidise NADH upon production of phenoxyl radicals in the presence of peroxidases and hydrogen peroxide.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Constantin, Rodrigo Polimeni& Nascimento, Gilson Soares do& Constantin, Renato Polimeni& Salgueiro, Clairce Luzia& Bracht, Adelar& Ishii-Iwamoto, Emy Luiza…[et al.]. 2013. Citrus Flavanones Affect Hepatic Fatty Acid Oxidation in Rats by Acting as Prooxidant Agents. BioMed Research International،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1004055
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Constantin, Rodrigo Polimeni…[et al.]. Citrus Flavanones Affect Hepatic Fatty Acid Oxidation in Rats by Acting as Prooxidant Agents. BioMed Research International No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1004055
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Constantin, Rodrigo Polimeni& Nascimento, Gilson Soares do& Constantin, Renato Polimeni& Salgueiro, Clairce Luzia& Bracht, Adelar& Ishii-Iwamoto, Emy Luiza…[et al.]. Citrus Flavanones Affect Hepatic Fatty Acid Oxidation in Rats by Acting as Prooxidant Agents. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1004055
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1004055
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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