Citrus Flavanones Affect Hepatic Fatty Acid Oxidation in Rats by Acting as Prooxidant Agents
Joint Authors
Constantin, Rodrigo Polimeni
Nascimento, Gilson Soares do
Constantin, Renato Polimeni
Salgueiro, Clairce Luzia
Bracht, Adelar
Ishii-Iwamoto, Emy Luiza
Yamamoto, Nair Seiko
Constantin, Jorgete
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-31
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Citrus flavonoids have a wide range of biological activities and positive health effects on mammalian cells because of their antioxidant properties.
However, they also act as prooxidants and thus may interfere with metabolic pathways.
The purpose of this work was to evaluate the effects of three citrus flavanones, hesperidin, hesperetin, and naringenin, on several parameters linked to fatty acid oxidation in mitochondria, peroxisomes, and perfused livers of rats.
When exogenous octanoate was used as substrate, hesperetin and naringenin reduced the mitochondrial NADH/NAD+ ratio and stimulated the citric acid cycle without significant changes on oxygen uptake or ketogenesis.
When fatty acid oxidation from endogenous sources was evaluated, hesperetin and naringenin strongly reduced the mitochondrial NADH/NAD+ ratio.
They also inhibited both oxygen uptake and ketogenesis and stimulated the citric acid cycle.
Hesperidin, on the other hand, had little to no effect on these parameters.
These results confirm the hypothesis that citrus flavanones are able to induce a more oxidised state in liver cells, altering parameters related to hepatic fatty acid oxidation.
The prooxidant effect is most likely a consequence of the ability of these substances to oxidise NADH upon production of phenoxyl radicals in the presence of peroxidases and hydrogen peroxide.
American Psychological Association (APA)
Constantin, Rodrigo Polimeni& Nascimento, Gilson Soares do& Constantin, Renato Polimeni& Salgueiro, Clairce Luzia& Bracht, Adelar& Ishii-Iwamoto, Emy Luiza…[et al.]. 2013. Citrus Flavanones Affect Hepatic Fatty Acid Oxidation in Rats by Acting as Prooxidant Agents. BioMed Research International،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1004055
Modern Language Association (MLA)
Constantin, Rodrigo Polimeni…[et al.]. Citrus Flavanones Affect Hepatic Fatty Acid Oxidation in Rats by Acting as Prooxidant Agents. BioMed Research International No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1004055
American Medical Association (AMA)
Constantin, Rodrigo Polimeni& Nascimento, Gilson Soares do& Constantin, Renato Polimeni& Salgueiro, Clairce Luzia& Bracht, Adelar& Ishii-Iwamoto, Emy Luiza…[et al.]. Citrus Flavanones Affect Hepatic Fatty Acid Oxidation in Rats by Acting as Prooxidant Agents. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1004055
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004055