Natural Oncolytic Activity of Live-Attenuated Measles Virus against Human Lung and Colorectal Adenocarcinomas
المؤلفون المشاركون
Boisgerault, Nicolas
Guillerme, Jean-Baptiste
Pouliquen, Daniel
Mesel-Lemoine, Mariana
Achard, Carole
Combredet, Chantal
Fonteneau, Jean-François
Tangy, Frédéric
Grégoire, Marc
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-03-17
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Lung and colorectal cancers are responsible for approximately 2 million deaths each year worldwide.
Despite continual improvements, clinical management of these diseases remains challenging and development of novel therapies with increased efficacy is critical to address these major public health issues.
Oncolytic viruses have shown promising results against cancers that are resistant to conventional anticancer therapies.
Vaccine strains of measles virus (MV) exhibit such natural antitumor properties by preferentially targeting cancer cells.
We tested the ability of live-attenuated Schwarz strain of MV to specifically infect tumor cells derived from human lung and colorectal adenocarcinomas and demonstrated that live-attenuated MV exhibits oncolytic properties against these two aggressive neoplasms.
We also showed that Schwarz MV was able to prevent uncontrollable growth of large, established lung and colorectal adenocarcinoma xenografts in nude mice.
Moreover, MV oncolysis is associated with in vivo activation of caspase-3 in colorectal cancer model, as shown by immunohistochemical staining.
Our results provide new arguments for the use of MV as an antitumor therapy against aggressive human malignancies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Boisgerault, Nicolas& Guillerme, Jean-Baptiste& Pouliquen, Daniel& Mesel-Lemoine, Mariana& Achard, Carole& Combredet, Chantal…[et al.]. 2013. Natural Oncolytic Activity of Live-Attenuated Measles Virus against Human Lung and Colorectal Adenocarcinomas. BioMed Research International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1004167
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Boisgerault, Nicolas…[et al.]. Natural Oncolytic Activity of Live-Attenuated Measles Virus against Human Lung and Colorectal Adenocarcinomas. BioMed Research International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1004167
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Boisgerault, Nicolas& Guillerme, Jean-Baptiste& Pouliquen, Daniel& Mesel-Lemoine, Mariana& Achard, Carole& Combredet, Chantal…[et al.]. Natural Oncolytic Activity of Live-Attenuated Measles Virus against Human Lung and Colorectal Adenocarcinomas. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1004167
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1004167
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر