Natural Oncolytic Activity of Live-Attenuated Measles Virus against Human Lung and Colorectal Adenocarcinomas
Joint Authors
Boisgerault, Nicolas
Guillerme, Jean-Baptiste
Pouliquen, Daniel
Mesel-Lemoine, Mariana
Achard, Carole
Combredet, Chantal
Fonteneau, Jean-François
Tangy, Frédéric
Grégoire, Marc
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Lung and colorectal cancers are responsible for approximately 2 million deaths each year worldwide.
Despite continual improvements, clinical management of these diseases remains challenging and development of novel therapies with increased efficacy is critical to address these major public health issues.
Oncolytic viruses have shown promising results against cancers that are resistant to conventional anticancer therapies.
Vaccine strains of measles virus (MV) exhibit such natural antitumor properties by preferentially targeting cancer cells.
We tested the ability of live-attenuated Schwarz strain of MV to specifically infect tumor cells derived from human lung and colorectal adenocarcinomas and demonstrated that live-attenuated MV exhibits oncolytic properties against these two aggressive neoplasms.
We also showed that Schwarz MV was able to prevent uncontrollable growth of large, established lung and colorectal adenocarcinoma xenografts in nude mice.
Moreover, MV oncolysis is associated with in vivo activation of caspase-3 in colorectal cancer model, as shown by immunohistochemical staining.
Our results provide new arguments for the use of MV as an antitumor therapy against aggressive human malignancies.
American Psychological Association (APA)
Boisgerault, Nicolas& Guillerme, Jean-Baptiste& Pouliquen, Daniel& Mesel-Lemoine, Mariana& Achard, Carole& Combredet, Chantal…[et al.]. 2013. Natural Oncolytic Activity of Live-Attenuated Measles Virus against Human Lung and Colorectal Adenocarcinomas. BioMed Research International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1004167
Modern Language Association (MLA)
Boisgerault, Nicolas…[et al.]. Natural Oncolytic Activity of Live-Attenuated Measles Virus against Human Lung and Colorectal Adenocarcinomas. BioMed Research International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1004167
American Medical Association (AMA)
Boisgerault, Nicolas& Guillerme, Jean-Baptiste& Pouliquen, Daniel& Mesel-Lemoine, Mariana& Achard, Carole& Combredet, Chantal…[et al.]. Natural Oncolytic Activity of Live-Attenuated Measles Virus against Human Lung and Colorectal Adenocarcinomas. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1004167
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004167