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The Influence of Flightless I on Toll-Like-Receptor-Mediated Inflammation in a Murine Model of Diabetic Wound Healing
المؤلفون المشاركون
Cowin, Allison J.
Ruzehaji, Nadira
Mills, Stuart J.
Melville, Elizabeth
Arkell, Ruth
Fitridge, Robert
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-02-18
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Impaired wound healing and ulceration represent a serious complication of both type 1 and type 2 diabetes.
Cytoskeletal protein Flightless I (Flii) is an important inhibitor of wound repair, and reduced Flii gene expression in fibroblasts increased migration, proliferation, and adhesion.
As such it has the ability to influence all phases of wound healing including inflammation, remodelling and angiogenesis.
Flii has the potential to modulate inflammation through its interaction with MyD88 which it an adaptor protein for TLR4.
To assess the effect of Flii on the inflammatory response of diabetic wounds, we used a murine model of streptozocin-induced diabetes and Flii genetic mice.
Increased levels of Flii were detected in Flii transgenic murine wounds resulting in impaired healing which was exacerbated when diabetes was induced.
When Flii levels were reduced in diabetic wounds of Flii-deficient mice, healing was improved and decreased levels of TLR4 were observed.
In contrast, increasing the level of Flii in diabetic mouse wounds led to increased TLR4 and NF-κB production.
Treatment of murine diabetic wounds with neutralising antibodies to Flii led to an improvement in healing with decreased expression of TLR4.
Decreasing the level of Flii in diabetic wounds may therefore reduce the inflammatory response and improve healing.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ruzehaji, Nadira& Mills, Stuart J.& Melville, Elizabeth& Arkell, Ruth& Fitridge, Robert& Cowin, Allison J.. 2013. The Influence of Flightless I on Toll-Like-Receptor-Mediated Inflammation in a Murine Model of Diabetic Wound Healing. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1004175
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ruzehaji, Nadira…[et al.]. The Influence of Flightless I on Toll-Like-Receptor-Mediated Inflammation in a Murine Model of Diabetic Wound Healing. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1004175
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ruzehaji, Nadira& Mills, Stuart J.& Melville, Elizabeth& Arkell, Ruth& Fitridge, Robert& Cowin, Allison J.. The Influence of Flightless I on Toll-Like-Receptor-Mediated Inflammation in a Murine Model of Diabetic Wound Healing. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1004175
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1004175
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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