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The Influence of Flightless I on Toll-Like-Receptor-Mediated Inflammation in a Murine Model of Diabetic Wound Healing
Joint Authors
Cowin, Allison J.
Ruzehaji, Nadira
Mills, Stuart J.
Melville, Elizabeth
Arkell, Ruth
Fitridge, Robert
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Impaired wound healing and ulceration represent a serious complication of both type 1 and type 2 diabetes.
Cytoskeletal protein Flightless I (Flii) is an important inhibitor of wound repair, and reduced Flii gene expression in fibroblasts increased migration, proliferation, and adhesion.
As such it has the ability to influence all phases of wound healing including inflammation, remodelling and angiogenesis.
Flii has the potential to modulate inflammation through its interaction with MyD88 which it an adaptor protein for TLR4.
To assess the effect of Flii on the inflammatory response of diabetic wounds, we used a murine model of streptozocin-induced diabetes and Flii genetic mice.
Increased levels of Flii were detected in Flii transgenic murine wounds resulting in impaired healing which was exacerbated when diabetes was induced.
When Flii levels were reduced in diabetic wounds of Flii-deficient mice, healing was improved and decreased levels of TLR4 were observed.
In contrast, increasing the level of Flii in diabetic mouse wounds led to increased TLR4 and NF-κB production.
Treatment of murine diabetic wounds with neutralising antibodies to Flii led to an improvement in healing with decreased expression of TLR4.
Decreasing the level of Flii in diabetic wounds may therefore reduce the inflammatory response and improve healing.
American Psychological Association (APA)
Ruzehaji, Nadira& Mills, Stuart J.& Melville, Elizabeth& Arkell, Ruth& Fitridge, Robert& Cowin, Allison J.. 2013. The Influence of Flightless I on Toll-Like-Receptor-Mediated Inflammation in a Murine Model of Diabetic Wound Healing. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1004175
Modern Language Association (MLA)
Ruzehaji, Nadira…[et al.]. The Influence of Flightless I on Toll-Like-Receptor-Mediated Inflammation in a Murine Model of Diabetic Wound Healing. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1004175
American Medical Association (AMA)
Ruzehaji, Nadira& Mills, Stuart J.& Melville, Elizabeth& Arkell, Ruth& Fitridge, Robert& Cowin, Allison J.. The Influence of Flightless I on Toll-Like-Receptor-Mediated Inflammation in a Murine Model of Diabetic Wound Healing. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1004175
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004175