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A Review of Haptoglobin Typing Methods for Disease Association Study and Preventing Anaphylactic Transfusion Reaction
المؤلفون المشاركون
Kim, Taek Soo
Park, Kyoung Un
Song, Eun Young
Ko, Dae-Hyun
Chang, Ho Eun
Song, Junghan
Han, Kyou-Sup
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-02-21
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Haptoglobin, the product of the Hp gene, is a glycoprotein involved in the scavenging of free hemoglobin.
Haptoglobin levels increase or decrease in response to various acquired conditions, and they are also influenced by genetic predisposition.
There were 2 major alleles, Hp1 and Hp2, and 1 minor allele, Hpdel.
Many researchers have attempted to study the haptoglobin types and their association with disease; however, no definitive conclusions have been reached yet.
It is reported that patients who are genetically deficient in haptoglobin are at risk of anaphylaxis against blood components containing haptoglobin.
Haptoglobin genotypes also affect the reference intervals of haptoglobin levels.
Many studies have attempted to establish simple and accurate typing methods.
In this paper, we have broadly reviewed several methods for haptoglobin typing—phenotyping, Southern blotting, conventional PCR, real-time PCR, and loop-mediated isothermal amplification.
We discuss their characteristics, clinical applications, and limitations.
The phenotyping methods are time consuming and labor intensive and not designed to detect patients harboring Hpdel.
The rapid and robust haptoglobin genotyping may help in preventing fatal anaphylactic reactions and in establishing the relationships between the haptoglobin phenotypes and diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ko, Dae-Hyun& Chang, Ho Eun& Kim, Taek Soo& Song, Eun Young& Park, Kyoung Un& Song, Junghan…[et al.]. 2013. A Review of Haptoglobin Typing Methods for Disease Association Study and Preventing Anaphylactic Transfusion Reaction. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1004180
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ko, Dae-Hyun…[et al.]. A Review of Haptoglobin Typing Methods for Disease Association Study and Preventing Anaphylactic Transfusion Reaction. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1004180
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ko, Dae-Hyun& Chang, Ho Eun& Kim, Taek Soo& Song, Eun Young& Park, Kyoung Un& Song, Junghan…[et al.]. A Review of Haptoglobin Typing Methods for Disease Association Study and Preventing Anaphylactic Transfusion Reaction. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1004180
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1004180
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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