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A Review of Haptoglobin Typing Methods for Disease Association Study and Preventing Anaphylactic Transfusion Reaction
Joint Authors
Kim, Taek Soo
Park, Kyoung Un
Song, Eun Young
Ko, Dae-Hyun
Chang, Ho Eun
Song, Junghan
Han, Kyou-Sup
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-21
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Haptoglobin, the product of the Hp gene, is a glycoprotein involved in the scavenging of free hemoglobin.
Haptoglobin levels increase or decrease in response to various acquired conditions, and they are also influenced by genetic predisposition.
There were 2 major alleles, Hp1 and Hp2, and 1 minor allele, Hpdel.
Many researchers have attempted to study the haptoglobin types and their association with disease; however, no definitive conclusions have been reached yet.
It is reported that patients who are genetically deficient in haptoglobin are at risk of anaphylaxis against blood components containing haptoglobin.
Haptoglobin genotypes also affect the reference intervals of haptoglobin levels.
Many studies have attempted to establish simple and accurate typing methods.
In this paper, we have broadly reviewed several methods for haptoglobin typing—phenotyping, Southern blotting, conventional PCR, real-time PCR, and loop-mediated isothermal amplification.
We discuss their characteristics, clinical applications, and limitations.
The phenotyping methods are time consuming and labor intensive and not designed to detect patients harboring Hpdel.
The rapid and robust haptoglobin genotyping may help in preventing fatal anaphylactic reactions and in establishing the relationships between the haptoglobin phenotypes and diseases.
American Psychological Association (APA)
Ko, Dae-Hyun& Chang, Ho Eun& Kim, Taek Soo& Song, Eun Young& Park, Kyoung Un& Song, Junghan…[et al.]. 2013. A Review of Haptoglobin Typing Methods for Disease Association Study and Preventing Anaphylactic Transfusion Reaction. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1004180
Modern Language Association (MLA)
Ko, Dae-Hyun…[et al.]. A Review of Haptoglobin Typing Methods for Disease Association Study and Preventing Anaphylactic Transfusion Reaction. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1004180
American Medical Association (AMA)
Ko, Dae-Hyun& Chang, Ho Eun& Kim, Taek Soo& Song, Eun Young& Park, Kyoung Un& Song, Junghan…[et al.]. A Review of Haptoglobin Typing Methods for Disease Association Study and Preventing Anaphylactic Transfusion Reaction. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1004180
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004180