Protective Effect of 3,4-Methylenedioxyphenol (Sesamol) on Stress-Related Mucosal Disease in Rats
المؤلفون المشاركون
Hsu, Dur-Zong
Chen, Yi-Wei
Chu, Pei-Yi
Periasamy, Srinivasan
Liu, Ming-Yie
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-25
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Stress-related mucosal disease (SRMD) causes considerable morbidity and mortality in critically ill patients.
3,4-Methylenedioxyphenol (sesamol) has been reported to have potent antioxidative and anti-inflammatory properties.
The aim of this study was to investigate the effect of sesamol on water immersion restraint- (WIR-) induced SRMD in rats.
Rat gastric ulcer and hemorrhage were induced by WIR.
Rats were pretreated orally with various doses of sesamol (0.1, 0.3, and 1 mg/kg, resp.) 30 min before WIR.
Gastric mucosal ulceration, hemoglobin, lipid peroxidation, mucus secretion, proinflammatory cytokines, and nuclear factor (NF)-κB levels were determined 4 h after WIR.
In addition, the infiltration of neutrophil and macrophage into gastric mucosa was also determined after WIR.
Water immersion restraint increased gastric mucosal ulcer and hemorrhage, tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 levels but failed to affect mucosal lipid peroxidation and mucus secretion compared with non-WIR.
Sesamol significantly decreased gastric ulceration and hemorrhage and inhibited mucosal TNF-α, IL-1β, and IL-6 production and NF-κB activity in WIR-treated rats.
In addition, increased myeloperoxidase and CD68 levels in gastric mucosa were found in WIR-treated rats compared to non-WIR rats.
Sesamol did not affect myeloperoxidase but decreased CD68 levels in mucosa in WIR-treated rats.
Sesamol may protect against SRMD by inhibiting gastric mucosal proinflammatory cytokines in rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hsu, Dur-Zong& Chen, Yi-Wei& Chu, Pei-Yi& Periasamy, Srinivasan& Liu, Ming-Yie. 2013. Protective Effect of 3,4-Methylenedioxyphenol (Sesamol) on Stress-Related Mucosal Disease in Rats. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1004417
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hsu, Dur-Zong…[et al.]. Protective Effect of 3,4-Methylenedioxyphenol (Sesamol) on Stress-Related Mucosal Disease in Rats. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1004417
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hsu, Dur-Zong& Chen, Yi-Wei& Chu, Pei-Yi& Periasamy, Srinivasan& Liu, Ming-Yie. Protective Effect of 3,4-Methylenedioxyphenol (Sesamol) on Stress-Related Mucosal Disease in Rats. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1004417
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1004417
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر