Protective Effect of 3,4-Methylenedioxyphenol (Sesamol) on Stress-Related Mucosal Disease in Rats
Joint Authors
Hsu, Dur-Zong
Chen, Yi-Wei
Chu, Pei-Yi
Periasamy, Srinivasan
Liu, Ming-Yie
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-25
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Stress-related mucosal disease (SRMD) causes considerable morbidity and mortality in critically ill patients.
3,4-Methylenedioxyphenol (sesamol) has been reported to have potent antioxidative and anti-inflammatory properties.
The aim of this study was to investigate the effect of sesamol on water immersion restraint- (WIR-) induced SRMD in rats.
Rat gastric ulcer and hemorrhage were induced by WIR.
Rats were pretreated orally with various doses of sesamol (0.1, 0.3, and 1 mg/kg, resp.) 30 min before WIR.
Gastric mucosal ulceration, hemoglobin, lipid peroxidation, mucus secretion, proinflammatory cytokines, and nuclear factor (NF)-κB levels were determined 4 h after WIR.
In addition, the infiltration of neutrophil and macrophage into gastric mucosa was also determined after WIR.
Water immersion restraint increased gastric mucosal ulcer and hemorrhage, tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 levels but failed to affect mucosal lipid peroxidation and mucus secretion compared with non-WIR.
Sesamol significantly decreased gastric ulceration and hemorrhage and inhibited mucosal TNF-α, IL-1β, and IL-6 production and NF-κB activity in WIR-treated rats.
In addition, increased myeloperoxidase and CD68 levels in gastric mucosa were found in WIR-treated rats compared to non-WIR rats.
Sesamol did not affect myeloperoxidase but decreased CD68 levels in mucosa in WIR-treated rats.
Sesamol may protect against SRMD by inhibiting gastric mucosal proinflammatory cytokines in rats.
American Psychological Association (APA)
Hsu, Dur-Zong& Chen, Yi-Wei& Chu, Pei-Yi& Periasamy, Srinivasan& Liu, Ming-Yie. 2013. Protective Effect of 3,4-Methylenedioxyphenol (Sesamol) on Stress-Related Mucosal Disease in Rats. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1004417
Modern Language Association (MLA)
Hsu, Dur-Zong…[et al.]. Protective Effect of 3,4-Methylenedioxyphenol (Sesamol) on Stress-Related Mucosal Disease in Rats. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1004417
American Medical Association (AMA)
Hsu, Dur-Zong& Chen, Yi-Wei& Chu, Pei-Yi& Periasamy, Srinivasan& Liu, Ming-Yie. Protective Effect of 3,4-Methylenedioxyphenol (Sesamol) on Stress-Related Mucosal Disease in Rats. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1004417
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004417