NRAMP1, VDR, HLA-DRB1, and HLA-DQB1 Gene Polymorphisms in Susceptibility to Tuberculosis among the Chinese Kazakh Population: A Case-Control Study
المؤلفون المشاركون
Wu, Fang
Zhang, Wanjiang
Zhang, Le
Wu, Jiangdong
Li, Chunzhu
Meng, Xianjie
Wang, Xi
He, Peng
Zhang, Jie
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-01
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
To explore the potential role of natural-resistance-associated macrophage protein 1 (NRAMP1) gene, vitamin D receptor (VDR) gene, (human leukocyte antigen, (HLA-DRB1) HLA) -DRB1 gene, and HLA-DQB1 gene polymorphisms in susceptibility to tuberculosis (TB) in the Chinese Kazakh population.
Methods.
A case-control study was performed on the Chinese Kazak population.
Genetic polymorphisms of NRAMP1 gene (3′UTR) and VDR gene (TaqI and FokI) were analysed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and sequencing analysis in TB patients and healthy controls.
Genetic polymorphisms of HLA-DRB1 gene and HLA-DQB1 gene in the two groups were detected with polymerase chain reaction-sequence-specific primers (PCR-SSPs) technique and sequencing analysis.
Results.
There was statistically significant difference in the 3′UTR polymorphism between the TB patients and healthy controls in the Chinese Kazak population (P=0.002; OR = 1.859; 95% CI = 1.182–2.926).
Significant difference was observed in the FokI polymorphism between the TB patients and healthy controls (P=0.001; OR = 1.530; 95% CI = 1.007–2.325).
It does not disclose any significant association between the disease and TaqI (P>0.05).
Alleles HLA-DRB1*04 and HLA-DQB1*0201 occurred more frequently in patients than in controls (P=0.011 and 0.002; OR = 1.889 and 1.802; 95% CI = 1.153–3.095 and 1.230–2.639, resp.).
Conclusions.
Polymorphisms in the NRAMP1 gene, VDR gene, HLA-DRB1 gene, and HLA-DQB1 gene are statistically associated with susceptibility to TB in the Chinese Kazakh population.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Fang& Zhang, Wanjiang& Zhang, Le& Wu, Jiangdong& Li, Chunzhu& Meng, Xianjie…[et al.]. 2013. NRAMP1, VDR, HLA-DRB1, and HLA-DQB1 Gene Polymorphisms in Susceptibility to Tuberculosis among the Chinese Kazakh Population: A Case-Control Study. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1004423
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Fang…[et al.]. NRAMP1, VDR, HLA-DRB1, and HLA-DQB1 Gene Polymorphisms in Susceptibility to Tuberculosis among the Chinese Kazakh Population: A Case-Control Study. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1004423
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Fang& Zhang, Wanjiang& Zhang, Le& Wu, Jiangdong& Li, Chunzhu& Meng, Xianjie…[et al.]. NRAMP1, VDR, HLA-DRB1, and HLA-DQB1 Gene Polymorphisms in Susceptibility to Tuberculosis among the Chinese Kazakh Population: A Case-Control Study. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1004423
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1004423
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر