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NRAMP1, VDR, HLA-DRB1, and HLA-DQB1 Gene Polymorphisms in Susceptibility to Tuberculosis among the Chinese Kazakh Population: A Case-Control Study
Joint Authors
Wu, Fang
Zhang, Wanjiang
Zhang, Le
Wu, Jiangdong
Li, Chunzhu
Meng, Xianjie
Wang, Xi
He, Peng
Zhang, Jie
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
To explore the potential role of natural-resistance-associated macrophage protein 1 (NRAMP1) gene, vitamin D receptor (VDR) gene, (human leukocyte antigen, (HLA-DRB1) HLA) -DRB1 gene, and HLA-DQB1 gene polymorphisms in susceptibility to tuberculosis (TB) in the Chinese Kazakh population.
Methods.
A case-control study was performed on the Chinese Kazak population.
Genetic polymorphisms of NRAMP1 gene (3′UTR) and VDR gene (TaqI and FokI) were analysed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and sequencing analysis in TB patients and healthy controls.
Genetic polymorphisms of HLA-DRB1 gene and HLA-DQB1 gene in the two groups were detected with polymerase chain reaction-sequence-specific primers (PCR-SSPs) technique and sequencing analysis.
Results.
There was statistically significant difference in the 3′UTR polymorphism between the TB patients and healthy controls in the Chinese Kazak population (P=0.002; OR = 1.859; 95% CI = 1.182–2.926).
Significant difference was observed in the FokI polymorphism between the TB patients and healthy controls (P=0.001; OR = 1.530; 95% CI = 1.007–2.325).
It does not disclose any significant association between the disease and TaqI (P>0.05).
Alleles HLA-DRB1*04 and HLA-DQB1*0201 occurred more frequently in patients than in controls (P=0.011 and 0.002; OR = 1.889 and 1.802; 95% CI = 1.153–3.095 and 1.230–2.639, resp.).
Conclusions.
Polymorphisms in the NRAMP1 gene, VDR gene, HLA-DRB1 gene, and HLA-DQB1 gene are statistically associated with susceptibility to TB in the Chinese Kazakh population.
American Psychological Association (APA)
Wu, Fang& Zhang, Wanjiang& Zhang, Le& Wu, Jiangdong& Li, Chunzhu& Meng, Xianjie…[et al.]. 2013. NRAMP1, VDR, HLA-DRB1, and HLA-DQB1 Gene Polymorphisms in Susceptibility to Tuberculosis among the Chinese Kazakh Population: A Case-Control Study. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1004423
Modern Language Association (MLA)
Wu, Fang…[et al.]. NRAMP1, VDR, HLA-DRB1, and HLA-DQB1 Gene Polymorphisms in Susceptibility to Tuberculosis among the Chinese Kazakh Population: A Case-Control Study. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1004423
American Medical Association (AMA)
Wu, Fang& Zhang, Wanjiang& Zhang, Le& Wu, Jiangdong& Li, Chunzhu& Meng, Xianjie…[et al.]. NRAMP1, VDR, HLA-DRB1, and HLA-DQB1 Gene Polymorphisms in Susceptibility to Tuberculosis among the Chinese Kazakh Population: A Case-Control Study. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1004423
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004423