Systems Approaches Evaluating the Perturbation of Xenobiotic Metabolism in Response to Cigarette Smoke Exposure in Nasal and Bronchial Tissues
المؤلفون المشاركون
Iskandar, Anita R.
Martin, Florian
Talikka, Marja
Schlage, Walter K.
Kostadinova, Radina
Mathis, Carole
Hoeng, Julia
Peitsch, Manuel C.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-03
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Capturing the effects of exposure in a specific target organ is a major challenge in risk assessment.
Exposure to cigarette smoke (CS) implicates the field of tissue injury in the lung as well as nasal and airway epithelia.
Xenobiotic metabolism in particular becomes an attractive tool for chemical risk assessment because of its responsiveness against toxic compounds, including those present in CS.
This study describes an efficient integration from transcriptomic data to quantitative measures, which reflect the responses against xenobiotics that are captured in a biological network model.
We show here that our novel systems approach can quantify the perturbation in the network model of xenobiotic metabolism.
We further show that this approach efficiently compares the perturbation upon CS exposure in bronchial and nasal epithelial cells in vivo samples obtained from smokers.
Our observation suggests the xenobiotic responses in the bronchial and nasal epithelial cells of smokers were similar to those observed in their respective organotypic models exposed to CS.
Furthermore, the results suggest that nasal tissue is a reliable surrogate to measure xenobiotic responses in bronchial tissue.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Iskandar, Anita R.& Martin, Florian& Talikka, Marja& Schlage, Walter K.& Kostadinova, Radina& Mathis, Carole…[et al.]. 2013. Systems Approaches Evaluating the Perturbation of Xenobiotic Metabolism in Response to Cigarette Smoke Exposure in Nasal and Bronchial Tissues. BioMed Research International،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-1004488
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Iskandar, Anita R.…[et al.]. Systems Approaches Evaluating the Perturbation of Xenobiotic Metabolism in Response to Cigarette Smoke Exposure in Nasal and Bronchial Tissues. BioMed Research International No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-1004488
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Iskandar, Anita R.& Martin, Florian& Talikka, Marja& Schlage, Walter K.& Kostadinova, Radina& Mathis, Carole…[et al.]. Systems Approaches Evaluating the Perturbation of Xenobiotic Metabolism in Response to Cigarette Smoke Exposure in Nasal and Bronchial Tissues. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-1004488
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1004488
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر