Systems Approaches Evaluating the Perturbation of Xenobiotic Metabolism in Response to Cigarette Smoke Exposure in Nasal and Bronchial Tissues
Joint Authors
Iskandar, Anita R.
Martin, Florian
Talikka, Marja
Schlage, Walter K.
Kostadinova, Radina
Mathis, Carole
Hoeng, Julia
Peitsch, Manuel C.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-03
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Capturing the effects of exposure in a specific target organ is a major challenge in risk assessment.
Exposure to cigarette smoke (CS) implicates the field of tissue injury in the lung as well as nasal and airway epithelia.
Xenobiotic metabolism in particular becomes an attractive tool for chemical risk assessment because of its responsiveness against toxic compounds, including those present in CS.
This study describes an efficient integration from transcriptomic data to quantitative measures, which reflect the responses against xenobiotics that are captured in a biological network model.
We show here that our novel systems approach can quantify the perturbation in the network model of xenobiotic metabolism.
We further show that this approach efficiently compares the perturbation upon CS exposure in bronchial and nasal epithelial cells in vivo samples obtained from smokers.
Our observation suggests the xenobiotic responses in the bronchial and nasal epithelial cells of smokers were similar to those observed in their respective organotypic models exposed to CS.
Furthermore, the results suggest that nasal tissue is a reliable surrogate to measure xenobiotic responses in bronchial tissue.
American Psychological Association (APA)
Iskandar, Anita R.& Martin, Florian& Talikka, Marja& Schlage, Walter K.& Kostadinova, Radina& Mathis, Carole…[et al.]. 2013. Systems Approaches Evaluating the Perturbation of Xenobiotic Metabolism in Response to Cigarette Smoke Exposure in Nasal and Bronchial Tissues. BioMed Research International،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-1004488
Modern Language Association (MLA)
Iskandar, Anita R.…[et al.]. Systems Approaches Evaluating the Perturbation of Xenobiotic Metabolism in Response to Cigarette Smoke Exposure in Nasal and Bronchial Tissues. BioMed Research International No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-1004488
American Medical Association (AMA)
Iskandar, Anita R.& Martin, Florian& Talikka, Marja& Schlage, Walter K.& Kostadinova, Radina& Mathis, Carole…[et al.]. Systems Approaches Evaluating the Perturbation of Xenobiotic Metabolism in Response to Cigarette Smoke Exposure in Nasal and Bronchial Tissues. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-1004488
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004488