Higher Incidence of Lung Adenocarcinomas Induced by DMBA in Connexin 43 Heterozygous Knockout Mice
المؤلفون المشاركون
Duro de Oliveira, Krishna
Vannucci Tedardi, Marcello
Cogliati, Bruno
Zaidan Dagli, Maria Lúcia
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-03
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Gap junctions are communicating junctions which are important for tissue homeostasis, and their disruption is involved in carcinogenic processes.
This study aimed to verify the influence of deletion of one allele of the Connexin 43 gene on cancer incidence in different organs.
The 7, 12-dimethylbenzanthracene (DMBA) carcinogenic model, using hebdomadary doses by gavage of 9 mg per animal, was used to induce tumors in Connexin 43 heterozygous or wild-type mice.
The experiment began in the eighth week of the mice life, and all of them were euthanized when reaching inadequate physical condition, or at the end of 53 weeks.
No statistical differences occurred for weight gain and cancer survival time (P=0.9853) between heterozygous and wild-type mice.
Cx43+/− mice presented significantly higher susceptibility to lung cancer (P=0.0200) which was not evidenced for benign neoplasms (P=0.3449).
In addition, incidence of ovarian neoplasms was 2.5-fold higher in Cx43+/− mice, although not statistically significant.
Other organs showed a very similar cancer occurrence between Cx43 groups.
The experiment strengthens the evidence of the relationship between Connexin 43 deficiency and carcinogenesis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Duro de Oliveira, Krishna& Vannucci Tedardi, Marcello& Cogliati, Bruno& Zaidan Dagli, Maria Lúcia. 2013. Higher Incidence of Lung Adenocarcinomas Induced by DMBA in Connexin 43 Heterozygous Knockout Mice. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1004731
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Duro de Oliveira, Krishna…[et al.]. Higher Incidence of Lung Adenocarcinomas Induced by DMBA in Connexin 43 Heterozygous Knockout Mice. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1004731
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Duro de Oliveira, Krishna& Vannucci Tedardi, Marcello& Cogliati, Bruno& Zaidan Dagli, Maria Lúcia. Higher Incidence of Lung Adenocarcinomas Induced by DMBA in Connexin 43 Heterozygous Knockout Mice. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1004731
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1004731
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر