Higher Incidence of Lung Adenocarcinomas Induced by DMBA in Connexin 43 Heterozygous Knockout Mice
Joint Authors
Duro de Oliveira, Krishna
Vannucci Tedardi, Marcello
Cogliati, Bruno
Zaidan Dagli, Maria Lúcia
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Gap junctions are communicating junctions which are important for tissue homeostasis, and their disruption is involved in carcinogenic processes.
This study aimed to verify the influence of deletion of one allele of the Connexin 43 gene on cancer incidence in different organs.
The 7, 12-dimethylbenzanthracene (DMBA) carcinogenic model, using hebdomadary doses by gavage of 9 mg per animal, was used to induce tumors in Connexin 43 heterozygous or wild-type mice.
The experiment began in the eighth week of the mice life, and all of them were euthanized when reaching inadequate physical condition, or at the end of 53 weeks.
No statistical differences occurred for weight gain and cancer survival time (P=0.9853) between heterozygous and wild-type mice.
Cx43+/− mice presented significantly higher susceptibility to lung cancer (P=0.0200) which was not evidenced for benign neoplasms (P=0.3449).
In addition, incidence of ovarian neoplasms was 2.5-fold higher in Cx43+/− mice, although not statistically significant.
Other organs showed a very similar cancer occurrence between Cx43 groups.
The experiment strengthens the evidence of the relationship between Connexin 43 deficiency and carcinogenesis.
American Psychological Association (APA)
Duro de Oliveira, Krishna& Vannucci Tedardi, Marcello& Cogliati, Bruno& Zaidan Dagli, Maria Lúcia. 2013. Higher Incidence of Lung Adenocarcinomas Induced by DMBA in Connexin 43 Heterozygous Knockout Mice. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1004731
Modern Language Association (MLA)
Duro de Oliveira, Krishna…[et al.]. Higher Incidence of Lung Adenocarcinomas Induced by DMBA in Connexin 43 Heterozygous Knockout Mice. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1004731
American Medical Association (AMA)
Duro de Oliveira, Krishna& Vannucci Tedardi, Marcello& Cogliati, Bruno& Zaidan Dagli, Maria Lúcia. Higher Incidence of Lung Adenocarcinomas Induced by DMBA in Connexin 43 Heterozygous Knockout Mice. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1004731
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004731