In Vivo Caprine Model for Osteomyelitis and Evaluation of Biofilm-Resistant Intramedullary Nails
المؤلفون المشاركون
Tran, Nhiem
Tran, Phong A.
Jarrell, John D.
Engiles, Julie B.
Thomas, Nathan P.
Young, Matthew D.
Hayda, Roman A.
Born, Christopher T.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-11
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Bone infection remains a formidable challenge to the medical field.
The goal of the current study is to evaluate antibacterial coatings in vitro and to develop a large animal model to assess coated bone implants.
A novel coating consisting of titanium oxide and siloxane polymer doped with silver was created by metal-organic methods.
The coating was tested in vitro using rapid screening techniques to determine compositions which inhibited Staphylococcus aureus growth, while not affecting osteoblast viability.
The coating was then applied to intramedullary nails and evaluated in vivo in a caprine model.
In this pilot study, a fracture was created in the tibia of the goat, and Staphylococcus aureus was inoculated directly into the bone canal.
The fractures were fixed by either coated (treated) or non-coated intramedullary nails (control) for 5 weeks.
Clinical observations as well as microbiology, mechanical, radiology, and histology testing were used to compare the animals.
The treated goat was able to walk using all four limbs after 5 weeks, while the control was unwilling to bear weight on the fixed leg.
These results suggest the antimicrobial potential of the hybrid coating and the feasibility of the goat model for antimicrobial coated intramedullary implant evaluation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tran, Nhiem& Tran, Phong A.& Jarrell, John D.& Engiles, Julie B.& Thomas, Nathan P.& Young, Matthew D.…[et al.]. 2013. In Vivo Caprine Model for Osteomyelitis and Evaluation of Biofilm-Resistant Intramedullary Nails. BioMed Research International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1004825
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tran, Nhiem…[et al.]. In Vivo Caprine Model for Osteomyelitis and Evaluation of Biofilm-Resistant Intramedullary Nails. BioMed Research International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1004825
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tran, Nhiem& Tran, Phong A.& Jarrell, John D.& Engiles, Julie B.& Thomas, Nathan P.& Young, Matthew D.…[et al.]. In Vivo Caprine Model for Osteomyelitis and Evaluation of Biofilm-Resistant Intramedullary Nails. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1004825
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1004825
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر