In Vivo Caprine Model for Osteomyelitis and Evaluation of Biofilm-Resistant Intramedullary Nails
Joint Authors
Tran, Nhiem
Tran, Phong A.
Jarrell, John D.
Engiles, Julie B.
Thomas, Nathan P.
Young, Matthew D.
Hayda, Roman A.
Born, Christopher T.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Bone infection remains a formidable challenge to the medical field.
The goal of the current study is to evaluate antibacterial coatings in vitro and to develop a large animal model to assess coated bone implants.
A novel coating consisting of titanium oxide and siloxane polymer doped with silver was created by metal-organic methods.
The coating was tested in vitro using rapid screening techniques to determine compositions which inhibited Staphylococcus aureus growth, while not affecting osteoblast viability.
The coating was then applied to intramedullary nails and evaluated in vivo in a caprine model.
In this pilot study, a fracture was created in the tibia of the goat, and Staphylococcus aureus was inoculated directly into the bone canal.
The fractures were fixed by either coated (treated) or non-coated intramedullary nails (control) for 5 weeks.
Clinical observations as well as microbiology, mechanical, radiology, and histology testing were used to compare the animals.
The treated goat was able to walk using all four limbs after 5 weeks, while the control was unwilling to bear weight on the fixed leg.
These results suggest the antimicrobial potential of the hybrid coating and the feasibility of the goat model for antimicrobial coated intramedullary implant evaluation.
American Psychological Association (APA)
Tran, Nhiem& Tran, Phong A.& Jarrell, John D.& Engiles, Julie B.& Thomas, Nathan P.& Young, Matthew D.…[et al.]. 2013. In Vivo Caprine Model for Osteomyelitis and Evaluation of Biofilm-Resistant Intramedullary Nails. BioMed Research International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1004825
Modern Language Association (MLA)
Tran, Nhiem…[et al.]. In Vivo Caprine Model for Osteomyelitis and Evaluation of Biofilm-Resistant Intramedullary Nails. BioMed Research International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1004825
American Medical Association (AMA)
Tran, Nhiem& Tran, Phong A.& Jarrell, John D.& Engiles, Julie B.& Thomas, Nathan P.& Young, Matthew D.…[et al.]. In Vivo Caprine Model for Osteomyelitis and Evaluation of Biofilm-Resistant Intramedullary Nails. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1004825
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004825