Role of Intracellular Ca2+ and Na+Ca2+ Exchanger in the Pathogenesis of Contrast-Induced Acute Kidney Injury

الملخص EN

The precise mechanisms underlying contrast-induced acute kidney injury (CI-AKI) are not well understood.

Intracellular Ca2+ overload is considered to be a key factor in CI-AKI.

Voltage-dependent Ca2+ channel (VDC) and Na+/Ca2+ exchanger (NCX) system are the main pathways of intracellular Ca2+ overload in pathological conditions.

Here, we review the potential underlying mechanisms involved in CI-AKI and discuss the role of NCX-mediated intracellular Ca2+ overload in the contrast media-induced renal tubular cell injury and renal hemodynamic disorder.