Different Impact of Pretransplant Anti-HLA Antibodies Detected by Luminex in Highly Sensitized Renal Transplanted Patients
المؤلفون المشاركون
Pérez-Flores, Isabel
Santiago, Jose Luis
Calvo-Romero, Natividad
Barrientos-Guzmán, Alberto
Sánchez-Fructuoso, Ana Isabel
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-05
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
It is well know that anti-HLA antibodies are an important obstacle in kidney transplantation.
Our aim was to study the clinical impact of pretransplant donor specific anti-HLA antibodies (HLA-DSA), in highly sensitized (HS) patients.
We analyzed retrospectively the day-of-transplant sera by Luminex Single Antigen Assay (LSA) in HS patients, and the results were correlated with episodes of humoral and cellular rejection as well as with graft and patient survival.
All HS subjects received the same induction therapy and rejection episodes were biopsy proven.
Thirteen patients (56.5%) preformed HLA-DSA, and we observed higher incidence of acute rejection in aforementioned patients than in the pre-transplant negatives DSA recipients (77% versus 30%, P=0.03).
The one-year graft survival was significantly reduced in positive pre-transplant HLA-DSA patients (60% versus 100%, P=0.01 Breslow).
The positive predicted value of HLA-DSA in relation to rejection reached 100% if patients lost their previous graft in the first year after transplant.
Among anti-HLA antibodies present in patients before transplant, HLA-DSA were significantly associated with high risk of acute humoral and cellular rejection and reduced graft survival in posttransplant outcome.
The negative impact of these antibodies was even higher when patients suffered an early loss of the previous transplant.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pérez-Flores, Isabel& Santiago, Jose Luis& Calvo-Romero, Natividad& Barrientos-Guzmán, Alberto& Sánchez-Fructuoso, Ana Isabel. 2013. Different Impact of Pretransplant Anti-HLA Antibodies Detected by Luminex in Highly Sensitized Renal Transplanted Patients. BioMed Research International،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1004999
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pérez-Flores, Isabel…[et al.]. Different Impact of Pretransplant Anti-HLA Antibodies Detected by Luminex in Highly Sensitized Renal Transplanted Patients. BioMed Research International No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1004999
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pérez-Flores, Isabel& Santiago, Jose Luis& Calvo-Romero, Natividad& Barrientos-Guzmán, Alberto& Sánchez-Fructuoso, Ana Isabel. Different Impact of Pretransplant Anti-HLA Antibodies Detected by Luminex in Highly Sensitized Renal Transplanted Patients. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1004999
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1004999
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر