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Different Impact of Pretransplant Anti-HLA Antibodies Detected by Luminex in Highly Sensitized Renal Transplanted Patients
Joint Authors
Pérez-Flores, Isabel
Santiago, Jose Luis
Calvo-Romero, Natividad
Barrientos-Guzmán, Alberto
Sánchez-Fructuoso, Ana Isabel
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-05
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
It is well know that anti-HLA antibodies are an important obstacle in kidney transplantation.
Our aim was to study the clinical impact of pretransplant donor specific anti-HLA antibodies (HLA-DSA), in highly sensitized (HS) patients.
We analyzed retrospectively the day-of-transplant sera by Luminex Single Antigen Assay (LSA) in HS patients, and the results were correlated with episodes of humoral and cellular rejection as well as with graft and patient survival.
All HS subjects received the same induction therapy and rejection episodes were biopsy proven.
Thirteen patients (56.5%) preformed HLA-DSA, and we observed higher incidence of acute rejection in aforementioned patients than in the pre-transplant negatives DSA recipients (77% versus 30%, P=0.03).
The one-year graft survival was significantly reduced in positive pre-transplant HLA-DSA patients (60% versus 100%, P=0.01 Breslow).
The positive predicted value of HLA-DSA in relation to rejection reached 100% if patients lost their previous graft in the first year after transplant.
Among anti-HLA antibodies present in patients before transplant, HLA-DSA were significantly associated with high risk of acute humoral and cellular rejection and reduced graft survival in posttransplant outcome.
The negative impact of these antibodies was even higher when patients suffered an early loss of the previous transplant.
American Psychological Association (APA)
Pérez-Flores, Isabel& Santiago, Jose Luis& Calvo-Romero, Natividad& Barrientos-Guzmán, Alberto& Sánchez-Fructuoso, Ana Isabel. 2013. Different Impact of Pretransplant Anti-HLA Antibodies Detected by Luminex in Highly Sensitized Renal Transplanted Patients. BioMed Research International،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1004999
Modern Language Association (MLA)
Pérez-Flores, Isabel…[et al.]. Different Impact of Pretransplant Anti-HLA Antibodies Detected by Luminex in Highly Sensitized Renal Transplanted Patients. BioMed Research International No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1004999
American Medical Association (AMA)
Pérez-Flores, Isabel& Santiago, Jose Luis& Calvo-Romero, Natividad& Barrientos-Guzmán, Alberto& Sánchez-Fructuoso, Ana Isabel. Different Impact of Pretransplant Anti-HLA Antibodies Detected by Luminex in Highly Sensitized Renal Transplanted Patients. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1004999
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004999