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Frequency and Characteristics of Infections Caused by Extended-Spectrum Beta-Lactamase-Producing Organisms in Neonates: A Prospective Cohort Study
المؤلفون المشاركون
Vijayakanthi, Nandini
Bahl, Dheeraj
Kaur, Nirmaljit
Maria, Arti
Dubey, Nand Kishore
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-24
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
This prospective cohort study was conducted to determine the frequency of infections caused by extended-spectrum beta-lactamase- (ESBL-) producing organisms, various bacteria producing ESBL, antibiotic susceptibility of these organisms, and the risk factors associated with these infections in a neonatal intensive care unit in a tertiary care hospital in North India.
Of the 150 neonates enrolled in the study, 47 culture-positive neonates were included in the study cohort and were divided into two groups: ESBL-positive (8 neonates) and ESBL-negative (39 neonates) cohorts.
Various organisms were isolated from 72 culture samples in these 47 neonates.
Of these, 10 culture samples grew ESBL-positive organisms and 62 samples grew ESBL-negative organisms.
The frequency of ESBL-producing organisms was found to be 5.3%.
ESBL infection incidence densities were found to be 3.4 per 1000 patient-days.
Klebsiella (60%) was the most common organism producing ESBL followed by Escherichia coli (30%) and Pseudomonas (10%).
Eighty percent of the ESBL-producing organisms were sensitive to piperacillin-tazobactam.
Risk factors found significant by univariate analysis (P<0.05) were preterm, low birthweight, perinatal asphyxia, respiratory distress syndrome, anaemia, metabolic acidosis, prolonged mechanical ventilation (>7 days), length of hospitalization, length of level 3 stay, prior antibiotic use, central venous catheter duration, peripherally inserted central venous catheter duration, and total parenteral nutrition duration.
Factors that retained significance in the logistic regression model were duration of hospital stay (adjusted OR: 0.958, CI: 0.920–0.997, and P value = 0.037) and gestational age (adjusted OR: 1.39, CI: 1.037–1.865, and P value = 0.028).
There was no significant difference in the mortality between the two groups.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vijayakanthi, Nandini& Bahl, Dheeraj& Kaur, Nirmaljit& Maria, Arti& Dubey, Nand Kishore. 2013. Frequency and Characteristics of Infections Caused by Extended-Spectrum Beta-Lactamase-Producing Organisms in Neonates: A Prospective Cohort Study. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1005045
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vijayakanthi, Nandini…[et al.]. Frequency and Characteristics of Infections Caused by Extended-Spectrum Beta-Lactamase-Producing Organisms in Neonates: A Prospective Cohort Study. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1005045
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vijayakanthi, Nandini& Bahl, Dheeraj& Kaur, Nirmaljit& Maria, Arti& Dubey, Nand Kishore. Frequency and Characteristics of Infections Caused by Extended-Spectrum Beta-Lactamase-Producing Organisms in Neonates: A Prospective Cohort Study. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1005045
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1005045
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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