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Frequency and Characteristics of Infections Caused by Extended-Spectrum Beta-Lactamase-Producing Organisms in Neonates: A Prospective Cohort Study
Joint Authors
Vijayakanthi, Nandini
Bahl, Dheeraj
Kaur, Nirmaljit
Maria, Arti
Dubey, Nand Kishore
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
This prospective cohort study was conducted to determine the frequency of infections caused by extended-spectrum beta-lactamase- (ESBL-) producing organisms, various bacteria producing ESBL, antibiotic susceptibility of these organisms, and the risk factors associated with these infections in a neonatal intensive care unit in a tertiary care hospital in North India.
Of the 150 neonates enrolled in the study, 47 culture-positive neonates were included in the study cohort and were divided into two groups: ESBL-positive (8 neonates) and ESBL-negative (39 neonates) cohorts.
Various organisms were isolated from 72 culture samples in these 47 neonates.
Of these, 10 culture samples grew ESBL-positive organisms and 62 samples grew ESBL-negative organisms.
The frequency of ESBL-producing organisms was found to be 5.3%.
ESBL infection incidence densities were found to be 3.4 per 1000 patient-days.
Klebsiella (60%) was the most common organism producing ESBL followed by Escherichia coli (30%) and Pseudomonas (10%).
Eighty percent of the ESBL-producing organisms were sensitive to piperacillin-tazobactam.
Risk factors found significant by univariate analysis (P<0.05) were preterm, low birthweight, perinatal asphyxia, respiratory distress syndrome, anaemia, metabolic acidosis, prolonged mechanical ventilation (>7 days), length of hospitalization, length of level 3 stay, prior antibiotic use, central venous catheter duration, peripherally inserted central venous catheter duration, and total parenteral nutrition duration.
Factors that retained significance in the logistic regression model were duration of hospital stay (adjusted OR: 0.958, CI: 0.920–0.997, and P value = 0.037) and gestational age (adjusted OR: 1.39, CI: 1.037–1.865, and P value = 0.028).
There was no significant difference in the mortality between the two groups.
American Psychological Association (APA)
Vijayakanthi, Nandini& Bahl, Dheeraj& Kaur, Nirmaljit& Maria, Arti& Dubey, Nand Kishore. 2013. Frequency and Characteristics of Infections Caused by Extended-Spectrum Beta-Lactamase-Producing Organisms in Neonates: A Prospective Cohort Study. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1005045
Modern Language Association (MLA)
Vijayakanthi, Nandini…[et al.]. Frequency and Characteristics of Infections Caused by Extended-Spectrum Beta-Lactamase-Producing Organisms in Neonates: A Prospective Cohort Study. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1005045
American Medical Association (AMA)
Vijayakanthi, Nandini& Bahl, Dheeraj& Kaur, Nirmaljit& Maria, Arti& Dubey, Nand Kishore. Frequency and Characteristics of Infections Caused by Extended-Spectrum Beta-Lactamase-Producing Organisms in Neonates: A Prospective Cohort Study. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1005045
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005045