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A MicroRNA Component of the Neoplastic Microenvironment: Microregulators with Far-Reaching Impact
المؤلفون المشاركون
Li, Xiaolei
Wu, Zhiqiang
Han, Weidong
Fu, Xiaobing
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-04
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The interplay between tumor cells and their microenvironment plays a pivotal role in tumor development and progression.
Although a growing body of evidence has established the importance of the tumor microenvironment, an understanding of the crosstalk between its components and cancer cells remains elusive.
The pathways triggered by microenvironmental factors could modulate cancer-related gene transcription, also affecting small noncoding RNAs, microRNAs, which have emerged as key posttranscriptional regulators of gene expression, directly involved in human cancers.
Although microRNAs regulate most biological mechanisms, their role in the tumor microenvironment has only recently become the focus of intense research.
In this paper, we focus on the intertwined connection between the tumor microenvironment and aberrant expression of microRNAs involved in carcinogenesis.
We also discuss the emerging roles of microRNAs in the tumor microenvironment as it relates to cancer progression.
We conclude that microRNAs are critical for our understanding of the development of cancer, and that targeting microRNA signaling pathways in the microenvironment as well as in tumor cells opens new therapeutic avenues to the global control of cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Xiaolei& Wu, Zhiqiang& Fu, Xiaobing& Han, Weidong. 2012. A MicroRNA Component of the Neoplastic Microenvironment: Microregulators with Far-Reaching Impact. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1005074
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Xiaolei…[et al.]. A MicroRNA Component of the Neoplastic Microenvironment: Microregulators with Far-Reaching Impact. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1005074
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Xiaolei& Wu, Zhiqiang& Fu, Xiaobing& Han, Weidong. A MicroRNA Component of the Neoplastic Microenvironment: Microregulators with Far-Reaching Impact. BioMed Research International. 2012. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1005074
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1005074
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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