A MicroRNA Component of the Neoplastic Microenvironment: Microregulators with Far-Reaching Impact
Joint Authors
Li, Xiaolei
Wu, Zhiqiang
Han, Weidong
Fu, Xiaobing
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The interplay between tumor cells and their microenvironment plays a pivotal role in tumor development and progression.
Although a growing body of evidence has established the importance of the tumor microenvironment, an understanding of the crosstalk between its components and cancer cells remains elusive.
The pathways triggered by microenvironmental factors could modulate cancer-related gene transcription, also affecting small noncoding RNAs, microRNAs, which have emerged as key posttranscriptional regulators of gene expression, directly involved in human cancers.
Although microRNAs regulate most biological mechanisms, their role in the tumor microenvironment has only recently become the focus of intense research.
In this paper, we focus on the intertwined connection between the tumor microenvironment and aberrant expression of microRNAs involved in carcinogenesis.
We also discuss the emerging roles of microRNAs in the tumor microenvironment as it relates to cancer progression.
We conclude that microRNAs are critical for our understanding of the development of cancer, and that targeting microRNA signaling pathways in the microenvironment as well as in tumor cells opens new therapeutic avenues to the global control of cancer.
American Psychological Association (APA)
Li, Xiaolei& Wu, Zhiqiang& Fu, Xiaobing& Han, Weidong. 2012. A MicroRNA Component of the Neoplastic Microenvironment: Microregulators with Far-Reaching Impact. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1005074
Modern Language Association (MLA)
Li, Xiaolei…[et al.]. A MicroRNA Component of the Neoplastic Microenvironment: Microregulators with Far-Reaching Impact. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1005074
American Medical Association (AMA)
Li, Xiaolei& Wu, Zhiqiang& Fu, Xiaobing& Han, Weidong. A MicroRNA Component of the Neoplastic Microenvironment: Microregulators with Far-Reaching Impact. BioMed Research International. 2012. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1005074
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005074