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Serum Fetuin-A Levels Related with Microalbuminuria in Diet-Induced Obese Rats
المؤلفون المشاركون
Li, Yanyan
Sun, Xiaodong
Yu, Yerong
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-05-21
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The aim of the study was to investigate the association between elevated serum fetuin-A and increased urine albumin excretion in obese rats, and whether increased urine albumin excretion was modified by improving hepatic steatosis and lipid metabolism disorder.
Male Wistar rats 4 weeks in age were randomly divided into three groups and fed with normal chow (control group), high-fat chow (obesity group), or high-fat chow plus fenofibrate (fenofibrate group).
After 24 weeks, both body weight and visceral fat/body weight ratio in obese rats were higher than in controls.
A difference in serology markers and pathology associated with hepatic steatosis was also found among the three groups.
Serum fetuin-A and the expression of NF-κB in the liver were increased, while serum adiponectin was decreased in obese rats in comparison to controls (P<0.01).
Urinary albumin/creatinine ratio (ACR) was increased in the obesity group compared to controls (P<0.01).
The fenofibrate intervention reduced serum fetuin-A and NF-κB expression in the liver and increased serum adiponectin compared to obese rats and was accompanied by decrease in ACR.
A positive correlation was found between ACR and fetuin-A (r=0.602, P<0.01), and a negative correlation was found between ACR and adiponectin (r=−0.635, P<0.01).
We conclude that elevated fetuin-A levels are associated with microalbuminuria in obese rats, and abnormal albuminuria is reversible by improving hepatic steatosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Yanyan& Sun, Xiaodong& Yu, Yerong. 2013. Serum Fetuin-A Levels Related with Microalbuminuria in Diet-Induced Obese Rats. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1005134
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Yanyan…[et al.]. Serum Fetuin-A Levels Related with Microalbuminuria in Diet-Induced Obese Rats. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1005134
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Yanyan& Sun, Xiaodong& Yu, Yerong. Serum Fetuin-A Levels Related with Microalbuminuria in Diet-Induced Obese Rats. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1005134
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1005134
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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