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Serum Fetuin-A Levels Related with Microalbuminuria in Diet-Induced Obese Rats
Joint Authors
Li, Yanyan
Sun, Xiaodong
Yu, Yerong
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The aim of the study was to investigate the association between elevated serum fetuin-A and increased urine albumin excretion in obese rats, and whether increased urine albumin excretion was modified by improving hepatic steatosis and lipid metabolism disorder.
Male Wistar rats 4 weeks in age were randomly divided into three groups and fed with normal chow (control group), high-fat chow (obesity group), or high-fat chow plus fenofibrate (fenofibrate group).
After 24 weeks, both body weight and visceral fat/body weight ratio in obese rats were higher than in controls.
A difference in serology markers and pathology associated with hepatic steatosis was also found among the three groups.
Serum fetuin-A and the expression of NF-κB in the liver were increased, while serum adiponectin was decreased in obese rats in comparison to controls (P<0.01).
Urinary albumin/creatinine ratio (ACR) was increased in the obesity group compared to controls (P<0.01).
The fenofibrate intervention reduced serum fetuin-A and NF-κB expression in the liver and increased serum adiponectin compared to obese rats and was accompanied by decrease in ACR.
A positive correlation was found between ACR and fetuin-A (r=0.602, P<0.01), and a negative correlation was found between ACR and adiponectin (r=−0.635, P<0.01).
We conclude that elevated fetuin-A levels are associated with microalbuminuria in obese rats, and abnormal albuminuria is reversible by improving hepatic steatosis.
American Psychological Association (APA)
Li, Yanyan& Sun, Xiaodong& Yu, Yerong. 2013. Serum Fetuin-A Levels Related with Microalbuminuria in Diet-Induced Obese Rats. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1005134
Modern Language Association (MLA)
Li, Yanyan…[et al.]. Serum Fetuin-A Levels Related with Microalbuminuria in Diet-Induced Obese Rats. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1005134
American Medical Association (AMA)
Li, Yanyan& Sun, Xiaodong& Yu, Yerong. Serum Fetuin-A Levels Related with Microalbuminuria in Diet-Induced Obese Rats. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1005134
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005134