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Catecholaminergic Gene Variants: Contribution in ADHD and Associated Comorbid Attributes in the Eastern Indian Probands
المؤلفون المشاركون
Ghosh, Paramita
Sarkar, Kanyakumarika
Bhaduri, Nipa
Ray, Anirban
Sarkar, Keka
Sinha, Swagata
Mukhopadhyay, Kanchan
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-19
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Contribution of genes in attention deficit hyperactivity disorder (ADHD) has been explored in various populations, and several genes were speculated to contribute small but additive effects.
We have assessed variants in four genes, DDC (rs3837091 and rs3735273), DRD2 (rs1800496, rs1801028, and rs1799732), DRD4 (rs4646984 and rs4646983), and COMT (rs165599 and rs740603) in Indian ADHD subjects with comorbid attributes.
Cases were recruited following the Diagnostic and Statistical Manual for Mental Disorders-IV-TR after obtaining informed written consent.
DNA isolated from peripheral blood leukocytes of ADHD probands ( N = 170 ), their parents ( N = 310 ), and ethnically matched controls ( n = 180 ) was used for genotyping followed by population- and family-based analyses by the UNPHASED program.
DRD4 sites showed significant difference in allelic frequencies by case-control analysis, while DDC and COMT exhibited bias in familial transmission ( P < 0.05 ).
rs3837091 “AGAG,” rs3735273 “A,” rs1799732 “C,” rs740603 “G,” rs165599 “G” and single repeat alleles of rs4646984/rs4646983 showed positive correlation with co-morbid characteristics ( P < 0.05 ).
Multi dimensionality reduction analysis of case-control data revealed significant interactive effects of all four genes ( P < 0.001 ), while family-based data showed interaction between DDC and DRD2 ( P = 0.04 ).
This first study on these gene variants in Indo-Caucasoid ADHD probands and associated co-morbid conditions indicates altered dopaminergic neurotransmission in ADHD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ghosh, Paramita& Sarkar, Kanyakumarika& Bhaduri, Nipa& Ray, Anirban& Sarkar, Keka& Sinha, Swagata…[et al.]. 2013. Catecholaminergic Gene Variants: Contribution in ADHD and Associated Comorbid Attributes in the Eastern Indian Probands. BioMed Research International،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1005409
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ghosh, Paramita…[et al.]. Catecholaminergic Gene Variants: Contribution in ADHD and Associated Comorbid Attributes in the Eastern Indian Probands. BioMed Research International No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1005409
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ghosh, Paramita& Sarkar, Kanyakumarika& Bhaduri, Nipa& Ray, Anirban& Sarkar, Keka& Sinha, Swagata…[et al.]. Catecholaminergic Gene Variants: Contribution in ADHD and Associated Comorbid Attributes in the Eastern Indian Probands. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1005409
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1005409
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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