Catecholaminergic Gene Variants: Contribution in ADHD and Associated Comorbid Attributes in the Eastern Indian Probands
Joint Authors
Ghosh, Paramita
Sarkar, Kanyakumarika
Bhaduri, Nipa
Ray, Anirban
Sarkar, Keka
Sinha, Swagata
Mukhopadhyay, Kanchan
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Contribution of genes in attention deficit hyperactivity disorder (ADHD) has been explored in various populations, and several genes were speculated to contribute small but additive effects.
We have assessed variants in four genes, DDC (rs3837091 and rs3735273), DRD2 (rs1800496, rs1801028, and rs1799732), DRD4 (rs4646984 and rs4646983), and COMT (rs165599 and rs740603) in Indian ADHD subjects with comorbid attributes.
Cases were recruited following the Diagnostic and Statistical Manual for Mental Disorders-IV-TR after obtaining informed written consent.
DNA isolated from peripheral blood leukocytes of ADHD probands ( N = 170 ), their parents ( N = 310 ), and ethnically matched controls ( n = 180 ) was used for genotyping followed by population- and family-based analyses by the UNPHASED program.
DRD4 sites showed significant difference in allelic frequencies by case-control analysis, while DDC and COMT exhibited bias in familial transmission ( P < 0.05 ).
rs3837091 “AGAG,” rs3735273 “A,” rs1799732 “C,” rs740603 “G,” rs165599 “G” and single repeat alleles of rs4646984/rs4646983 showed positive correlation with co-morbid characteristics ( P < 0.05 ).
Multi dimensionality reduction analysis of case-control data revealed significant interactive effects of all four genes ( P < 0.001 ), while family-based data showed interaction between DDC and DRD2 ( P = 0.04 ).
This first study on these gene variants in Indo-Caucasoid ADHD probands and associated co-morbid conditions indicates altered dopaminergic neurotransmission in ADHD.
American Psychological Association (APA)
Ghosh, Paramita& Sarkar, Kanyakumarika& Bhaduri, Nipa& Ray, Anirban& Sarkar, Keka& Sinha, Swagata…[et al.]. 2013. Catecholaminergic Gene Variants: Contribution in ADHD and Associated Comorbid Attributes in the Eastern Indian Probands. BioMed Research International،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1005409
Modern Language Association (MLA)
Ghosh, Paramita…[et al.]. Catecholaminergic Gene Variants: Contribution in ADHD and Associated Comorbid Attributes in the Eastern Indian Probands. BioMed Research International No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1005409
American Medical Association (AMA)
Ghosh, Paramita& Sarkar, Kanyakumarika& Bhaduri, Nipa& Ray, Anirban& Sarkar, Keka& Sinha, Swagata…[et al.]. Catecholaminergic Gene Variants: Contribution in ADHD and Associated Comorbid Attributes in the Eastern Indian Probands. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1005409
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005409