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In Vivo Evaluation of Ethanolic Extract of Zingiber officinale Rhizomes for Its Protective Effect against Liver Cirrhosis
المؤلفون المشاركون
Hajrezaei, Maryam
Abdulla, Mahmood Ameen
Abdulaziz Bardi, Daleya
Halabi, Mohammed Farouq
Abdullah, Nor Azizan
Rouhollahi, Elham
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-12
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Zingiber officinale is a traditional medicine against various disorders including liver diseases.The aim of this study was to assess the hepatoprotective activity of the ethanolic extract of rhizomes of Z.
officinale (ERZO) against thioacetamide-induced hepatotoxicity in rats.
Five groups of male Sprague Dawley have been used.
In group 1 rats received intraperitoneal (i.p.) injection of normal saline while groups 2–5 received thioacetamide (TAA, 200 mg/kg; i.p.) for induction of liver cirrhosis, thrice weekly for eight weeks.
Group 3 received 50 mg/kg of silymarin.
The rats in groups 4 and 5 received 250 and 500 mg/kg of ERZO (dissolved in 10% Tween), respectively.
Hepatic damage was assessed grossly and microscopically for all of the groups.
Results confirmed the induction of liver cirrhosis in group 2 whilst administration of silymarin or ERZO significantly reduced the impact of thioacetamide toxicity.
These groups decreased fibrosis of the liver tissues.
Immunohistochemistry assessment against proliferating cell nuclear antigen did not show remarkable proliferation in the ERZO-treated rats when compared with group 2.
Moreover, factions of the ERZO extract were tested on Hep-G2 cells and showed antiproliferative activity (IC50 38–60 μg/mL).
This study showed hepatoprotective effect of ERZO.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abdulaziz Bardi, Daleya& Halabi, Mohammed Farouq& Abdullah, Nor Azizan& Rouhollahi, Elham& Hajrezaei, Maryam& Abdulla, Mahmood Ameen. 2013. In Vivo Evaluation of Ethanolic Extract of Zingiber officinale Rhizomes for Its Protective Effect against Liver Cirrhosis. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1005410
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abdulaziz Bardi, Daleya…[et al.]. In Vivo Evaluation of Ethanolic Extract of Zingiber officinale Rhizomes for Its Protective Effect against Liver Cirrhosis. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1005410
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abdulaziz Bardi, Daleya& Halabi, Mohammed Farouq& Abdullah, Nor Azizan& Rouhollahi, Elham& Hajrezaei, Maryam& Abdulla, Mahmood Ameen. In Vivo Evaluation of Ethanolic Extract of Zingiber officinale Rhizomes for Its Protective Effect against Liver Cirrhosis. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1005410
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1005410
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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