In Vivo Evaluation of Ethanolic Extract of Zingiber officinale Rhizomes for Its Protective Effect against Liver Cirrhosis
Joint Authors
Hajrezaei, Maryam
Abdulla, Mahmood Ameen
Abdulaziz Bardi, Daleya
Halabi, Mohammed Farouq
Abdullah, Nor Azizan
Rouhollahi, Elham
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Zingiber officinale is a traditional medicine against various disorders including liver diseases.The aim of this study was to assess the hepatoprotective activity of the ethanolic extract of rhizomes of Z.
officinale (ERZO) against thioacetamide-induced hepatotoxicity in rats.
Five groups of male Sprague Dawley have been used.
In group 1 rats received intraperitoneal (i.p.) injection of normal saline while groups 2–5 received thioacetamide (TAA, 200 mg/kg; i.p.) for induction of liver cirrhosis, thrice weekly for eight weeks.
Group 3 received 50 mg/kg of silymarin.
The rats in groups 4 and 5 received 250 and 500 mg/kg of ERZO (dissolved in 10% Tween), respectively.
Hepatic damage was assessed grossly and microscopically for all of the groups.
Results confirmed the induction of liver cirrhosis in group 2 whilst administration of silymarin or ERZO significantly reduced the impact of thioacetamide toxicity.
These groups decreased fibrosis of the liver tissues.
Immunohistochemistry assessment against proliferating cell nuclear antigen did not show remarkable proliferation in the ERZO-treated rats when compared with group 2.
Moreover, factions of the ERZO extract were tested on Hep-G2 cells and showed antiproliferative activity (IC50 38–60 μg/mL).
This study showed hepatoprotective effect of ERZO.
American Psychological Association (APA)
Abdulaziz Bardi, Daleya& Halabi, Mohammed Farouq& Abdullah, Nor Azizan& Rouhollahi, Elham& Hajrezaei, Maryam& Abdulla, Mahmood Ameen. 2013. In Vivo Evaluation of Ethanolic Extract of Zingiber officinale Rhizomes for Its Protective Effect against Liver Cirrhosis. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1005410
Modern Language Association (MLA)
Abdulaziz Bardi, Daleya…[et al.]. In Vivo Evaluation of Ethanolic Extract of Zingiber officinale Rhizomes for Its Protective Effect against Liver Cirrhosis. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1005410
American Medical Association (AMA)
Abdulaziz Bardi, Daleya& Halabi, Mohammed Farouq& Abdullah, Nor Azizan& Rouhollahi, Elham& Hajrezaei, Maryam& Abdulla, Mahmood Ameen. In Vivo Evaluation of Ethanolic Extract of Zingiber officinale Rhizomes for Its Protective Effect against Liver Cirrhosis. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1005410
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005410