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Loss of RASSF1A Expression in Colorectal Cancer and Its Association with K-ras Status
المؤلفون المشاركون
Cao, Dan
Chen, Ye
Tang, Yuan
Peng, Xing-Chen
Dong, Hang
Li, Long-Hao
Cheng, Ke
Ge, Jun
Liu, Ji-Yan
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-22
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The RAS-association domain family 1 A (RASSF1A) is a classical member of RAS effectors regulating cell proliferation and apoptosis.
Loss of RASSF1A expression may shift the balance towards a growth-promoting effect without the necessity of activating K-ras mutations.
Its potential association with K-ras mutations in colorectal cancer (CRC) is unclear.
Methods.
RASSF1A expression was examined in normal mucosa, adenoma, and tumor tissues of colon and rectum, respectively.
We examined the association of RASSF1A expression, mutations of K-ras, and EGFR status in 76 primary CRCs.
The relationship between clinicopathological characteristics and RASSF1A expression was also analyzed.
Results.
RASSF1A expression level decreased progressively in normal mucosa, adenoma and, tumor tissues, and the loss of RASSF1A expression occurred more frequently in tumor tissues.
Of 76 primary CRCs, loss of RASSF1A expression and/or K-ras mutations were detected in 77% cases.
Loss of RASSF1A expression was more frequent in K-ras wild-type than in mutation cases (63% versus 32%, P=0.011).
Conclusions.
Our study indicates that loss of RASSF1A may be involved in pathogenesis of CRC, its expression was found predominantly in K-ras wild-type CRCs, suggesting that it may be another way of affecting RAS signaling, in addition to K-ras mutations.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cao, Dan& Chen, Ye& Tang, Yuan& Peng, Xing-Chen& Dong, Hang& Li, Long-Hao…[et al.]. 2013. Loss of RASSF1A Expression in Colorectal Cancer and Its Association with K-ras Status. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1005558
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cao, Dan…[et al.]. Loss of RASSF1A Expression in Colorectal Cancer and Its Association with K-ras Status. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1005558
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cao, Dan& Chen, Ye& Tang, Yuan& Peng, Xing-Chen& Dong, Hang& Li, Long-Hao…[et al.]. Loss of RASSF1A Expression in Colorectal Cancer and Its Association with K-ras Status. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1005558
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1005558
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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