Loss of RASSF1A Expression in Colorectal Cancer and Its Association with K-ras Status
Joint Authors
Cao, Dan
Chen, Ye
Tang, Yuan
Peng, Xing-Chen
Dong, Hang
Li, Long-Hao
Cheng, Ke
Ge, Jun
Liu, Ji-Yan
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The RAS-association domain family 1 A (RASSF1A) is a classical member of RAS effectors regulating cell proliferation and apoptosis.
Loss of RASSF1A expression may shift the balance towards a growth-promoting effect without the necessity of activating K-ras mutations.
Its potential association with K-ras mutations in colorectal cancer (CRC) is unclear.
Methods.
RASSF1A expression was examined in normal mucosa, adenoma, and tumor tissues of colon and rectum, respectively.
We examined the association of RASSF1A expression, mutations of K-ras, and EGFR status in 76 primary CRCs.
The relationship between clinicopathological characteristics and RASSF1A expression was also analyzed.
Results.
RASSF1A expression level decreased progressively in normal mucosa, adenoma and, tumor tissues, and the loss of RASSF1A expression occurred more frequently in tumor tissues.
Of 76 primary CRCs, loss of RASSF1A expression and/or K-ras mutations were detected in 77% cases.
Loss of RASSF1A expression was more frequent in K-ras wild-type than in mutation cases (63% versus 32%, P=0.011).
Conclusions.
Our study indicates that loss of RASSF1A may be involved in pathogenesis of CRC, its expression was found predominantly in K-ras wild-type CRCs, suggesting that it may be another way of affecting RAS signaling, in addition to K-ras mutations.
American Psychological Association (APA)
Cao, Dan& Chen, Ye& Tang, Yuan& Peng, Xing-Chen& Dong, Hang& Li, Long-Hao…[et al.]. 2013. Loss of RASSF1A Expression in Colorectal Cancer and Its Association with K-ras Status. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1005558
Modern Language Association (MLA)
Cao, Dan…[et al.]. Loss of RASSF1A Expression in Colorectal Cancer and Its Association with K-ras Status. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1005558
American Medical Association (AMA)
Cao, Dan& Chen, Ye& Tang, Yuan& Peng, Xing-Chen& Dong, Hang& Li, Long-Hao…[et al.]. Loss of RASSF1A Expression in Colorectal Cancer and Its Association with K-ras Status. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1005558
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005558