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Growth Factors Serum Levels in Coronary Artery Disease Patients Scheduled for Bypass Surgery: Perioperative Dynamics and Comparisons with Healthy Volunteers
المؤلفون المشاركون
Karu, Inga
Starkopf, Joel
Zilmer, Kersti
Zilmer, Mihkel
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-28
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Vascular endothelial growth factors are important mediators for neovascularization of chronically ischemic adult heart, but their elevated values have also been connected with acute ischemia.
Coronary artery bypass grafting (CABG) is associated with activation of inflammatory processes.
We aimed to clarify whether the latter is also accompanied with acute changes in concentrations of vascular growth factors.
Methods.
Concentrations of growth factors VEGF and EGF, monocyte chemoattractant protein-1 (MCP-1), and a set of cytokines of 39 patients with stable coronary artery disease (CAD) were evaluated before and after CABG.
Preoperative values were compared with data of healthy volunteers.
Results.
In comparison with CAD patients, healthy controls had significantly higher values of VEGF (15.5 (10.05–35.3) and 119.4 (55.7–136.9) pg/mL, resp.), EGF (1.70 (1.14–3.18) and 37.3 (27.1–51.9) pg/mL, resp.), and MCP-1 (111.6 (81.75–171.9) and 156.9 (134.7–241.3) pg/mL, resp.).
MCP-1, but not others, demonstrated a significant rise throughout the postoperative period.
Proinflammatory interleukin-6 was significantly higher and anti-inflammatory IL-4 and IL-10 lower in patients with CAD.
Conclusions.
Patients with stable CAD have lower serum levels of growth factors than healthy volunteers.
MCP-1, but not VEGF and EGF, becomes elevated immediately after CABG.
Inflammatory status of CAD patients was drifted towards proinflammatory state.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Karu, Inga& Starkopf, Joel& Zilmer, Kersti& Zilmer, Mihkel. 2013. Growth Factors Serum Levels in Coronary Artery Disease Patients Scheduled for Bypass Surgery: Perioperative Dynamics and Comparisons with Healthy Volunteers. BioMed Research International،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1005578
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Karu, Inga…[et al.]. Growth Factors Serum Levels in Coronary Artery Disease Patients Scheduled for Bypass Surgery: Perioperative Dynamics and Comparisons with Healthy Volunteers. BioMed Research International No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1005578
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Karu, Inga& Starkopf, Joel& Zilmer, Kersti& Zilmer, Mihkel. Growth Factors Serum Levels in Coronary Artery Disease Patients Scheduled for Bypass Surgery: Perioperative Dynamics and Comparisons with Healthy Volunteers. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1005578
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1005578
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