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Growth Factors Serum Levels in Coronary Artery Disease Patients Scheduled for Bypass Surgery: Perioperative Dynamics and Comparisons with Healthy Volunteers
Joint Authors
Karu, Inga
Starkopf, Joel
Zilmer, Kersti
Zilmer, Mihkel
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-28
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Vascular endothelial growth factors are important mediators for neovascularization of chronically ischemic adult heart, but their elevated values have also been connected with acute ischemia.
Coronary artery bypass grafting (CABG) is associated with activation of inflammatory processes.
We aimed to clarify whether the latter is also accompanied with acute changes in concentrations of vascular growth factors.
Methods.
Concentrations of growth factors VEGF and EGF, monocyte chemoattractant protein-1 (MCP-1), and a set of cytokines of 39 patients with stable coronary artery disease (CAD) were evaluated before and after CABG.
Preoperative values were compared with data of healthy volunteers.
Results.
In comparison with CAD patients, healthy controls had significantly higher values of VEGF (15.5 (10.05–35.3) and 119.4 (55.7–136.9) pg/mL, resp.), EGF (1.70 (1.14–3.18) and 37.3 (27.1–51.9) pg/mL, resp.), and MCP-1 (111.6 (81.75–171.9) and 156.9 (134.7–241.3) pg/mL, resp.).
MCP-1, but not others, demonstrated a significant rise throughout the postoperative period.
Proinflammatory interleukin-6 was significantly higher and anti-inflammatory IL-4 and IL-10 lower in patients with CAD.
Conclusions.
Patients with stable CAD have lower serum levels of growth factors than healthy volunteers.
MCP-1, but not VEGF and EGF, becomes elevated immediately after CABG.
Inflammatory status of CAD patients was drifted towards proinflammatory state.
American Psychological Association (APA)
Karu, Inga& Starkopf, Joel& Zilmer, Kersti& Zilmer, Mihkel. 2013. Growth Factors Serum Levels in Coronary Artery Disease Patients Scheduled for Bypass Surgery: Perioperative Dynamics and Comparisons with Healthy Volunteers. BioMed Research International،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1005578
Modern Language Association (MLA)
Karu, Inga…[et al.]. Growth Factors Serum Levels in Coronary Artery Disease Patients Scheduled for Bypass Surgery: Perioperative Dynamics and Comparisons with Healthy Volunteers. BioMed Research International No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1005578
American Medical Association (AMA)
Karu, Inga& Starkopf, Joel& Zilmer, Kersti& Zilmer, Mihkel. Growth Factors Serum Levels in Coronary Artery Disease Patients Scheduled for Bypass Surgery: Perioperative Dynamics and Comparisons with Healthy Volunteers. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1005578
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005578